Using mouse models of allogeneic blood and marrow transplantation (alloBMT) to optimize therapies that prevent graft-versus-host-disease (GVHD) and maximize graft-versus-tumor (GVT) effects
Trainer
Carchman, Evie
Churpek, Jane
Coon, Joshua
Bioanalytical Chemistry, Chemical Biology, Systems Biology, Mass Spectrometry, Proteomics
Cosper, Pippa
Deming, Dustin
I am a gastrointestinal oncologist at the University of Wisconsin Carbone Cancer Center (UWCCC) and the William S Middleton Veterans Hospital. I have a subspecialty focus in the treatment of colon, rectal and anal cancers. My research aims to fundamentally change the way in which we treat gastrointestinal cancers to a more personalized approach.
Denlinger, Loren
Host-pathogen interactions; the role of macrophages in immunity to intracellular pathogens; innate immune responses like cytokine production & microbial killing amplified by extracellular nucleotide receptor known as P2X7 (significant functional diversity for this receptor exists between cell types & human subjects); role of P2X7 as candidate gene modulating the human innate immune responses of macrophages & airway epithelial cells to Chlamydia pneumoniae, contribution of responses of asthma
Denu, Ryan
My research program focuses on understanding epigenetic and transcriptional regulation of human sarcomas with the goal of identifying and validating novel therapeutic targets to treat sarcomas, a disease with poor outcomes and inadequate available treatment options. We seek to identify epigenetic drivers of cell state plasticity in different sarcoma subtypes. My lab integrates cutting-edge techniques including single cell and spatial epigenetic and transcriptional profiling to answer these questions. My goal is to readily translate these findings from my lab into novel therapeutics for my patients.