Bioanalytical Chemistry, Chemical Biology, Systems Biology, Mass Spectrometry, Proteomics
Evolution of host-microbe interactions, including both pathogenic and beneficial microbes. We are particularly interested in: i) the evolution of virulence, ii) determining the factors that shape host-microbe specificity, iii) exploring factors limiting and/or facilitating broad host jumps, iv) and host-microbe coevolutionary dynamics. Our main model system is the fungus-growing ant–microbe symbiosis.
I am a gastrointestinal oncologist at the University of Wisconsin Carbone Cancer Center (UWCCC) and the William S Middleton Veterans Hospital. I have a subspecialty focus in the treatment of colon, rectal and anal cancers. My research aims to fundamentally change the way in which we treat gastrointestinal cancers to a more personalized approach.
Host-pathogen interactions; the role of macrophages in immunity to intracellular pathogens; innate immune responses like cytokine production & microbial killing amplified by extracellular nucleotide receptor known as P2X7 (significant functional diversity for this receptor exists between cell types & human subjects); role of P2X7 as candidate gene modulating the human innate immune responses of macrophages & airway epithelial cells to Chlamydia pneumoniae, contribution of responses of asthma
The cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease
Type 1 diabetes (T1D) results from the destruction of the insulin-secreting b-cells by an immune mediated process. The increasing incidence of type 1 diabetes around the word, especially among children, has been of great concern.
Understanding host-pathogen interactions for human and simian immunodeficiency viruses