Position title: Assistant Professor
Phone: (608) 265-1042
Clinical Sciences Center
600 Highland Ave
Madison, WI 53792
MD, University of Wisconsin-Madison
I am a gastrointestinal oncologist at the University of Wisconsin Carbone Cancer Center (UWCCC) and the William S Middleton Veterans Hospital. I have a subspecialty focus in the treatment of colon, rectal and anal cancers. My research aims to fundamentally change the way in which we treat gastrointestinal cancers to a more personalized approach.
My laboratory is investigating kinase modulation of cellular signaling pathways driven by oncogenic mutant proteins. To screen combinations of targeted agents in the setting of specific genetic alterations, novel mouse models of colorectal cancer including tumors driven by a constitutively active PI3K [Cancer Research, 2012; PLoSOne, 2013; Oncogene, 2013]. In addition to my laboratory research, I have also been active in early phase clinical trials. I have developed the concepts and chaired NCI/CTEP sponsored phase I clinical trials including AZD6244 in combination with cetuximab for KRAS mutant colorectal cancer [ASCO Annual Meeting, 2012] and ABT-888 in combination with capecitabine and oxaliplatin for BRCA mutant tumors and gastrointestinal cancers.