The cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease
Type 1 diabetes (T1D) results from the destruction of the insulin-secreting b-cells by an immune mediated process. The increasing incidence of type 1 diabetes around the word, especially among children, has been of great concern.
Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Cardiovascular Systems Biology through High-resolution Mass Spectrometry-based Comparative Proteomics and Metabolomics
Extracellular modulators of cellular behaviors in development, homeostasis, and disease
1. Genomics and Molecular Imaging of Lung-Brain Metastasis
2. Defining the functional significance of bromodomain containing proteins in pan-cancer studies.
The capacity for complex tissue regeneration is unevenly distributed across species. Unlike human, zebrafish possess a remarkable potential to regenerate tissues such as amputated appendages and damaged heart muscles. Interest of my laboratory is to understand how and what genetic and epigenetic factors control tissue regeneration using adult zebrafish as a model system.
Guanine Nucleotide Binding Proteins, pancreatic beta-cell biology, insulin secretion, diabetes pathophysiology
Physiological and pathophysiological mechanisms underlying blood pressure regulation and hypertension. Fetal origins of hypertension and diabetes. Sex differences in vascular and metabolic function.