Position title: Associate Professor
Phone: (608) 265-5627
4148 UW Medical Foundation Centennial Building
1685 Highland Ave.
- Kimple Lab
PhD, Biochemistry & Biophysics, University of North Carolina-Chapel Hill
Postdoctoral,Pharmacology & Cancer Biology, Duke University
Guanine Nucleotide Binding Proteins, pancreatic beta-cell biology, insulin secretion, diabetes pathophysiology
Research in the Michelle Kimple lab is focused on how the endocrine cells of the pancreatic islet of Langerhans coordinate to regulate hormone secretion in response to glucose and other stimuli; impacting whole-body fuel metabolism. The Kimple Lab is especially interested in elucidating how G protein signaling networks regulate alpha-, beta-, and delta-cell function and their response to insults such as hyperglycemia, dyslipidemia, and inflammation (coincident with insulin resistance and type 2 diabetes) or immune infiltration (coincident with type 1 diabetes). The premise behind research in the Kimple lab is G protein-coupled receptors and their associated ligands, G proteins, and downstream effectors play key roles in early islet cell adaptation and resilience to external stressors, and that certain G protein signaling pathways become dysfunctional in the diabetic state, actively contributing to the pathophysiology of the disease and impacting the ability of certain classes of diabetes therapeutics to properly control blood glucose levels. It is the long-term goal of the Kimple Lab research program to identify and validate novel therapeutic targets to prevent or ameliorate the islet cell dysfunction of diabetes, improving the care and treatment of individuals with diabetes or preventing the disease in individuals with an underlying susceptibility.