Using mouse models of allogeneic blood and marrow transplantation (alloBMT) to optimize therapies that prevent graft-versus-host-disease (GVHD) and maximize graft-versus-tumor (GVT) effects
To define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses
Cell migration and chemotaxis, adhesive mechanisms that regulate cell migration and the role of integrin signaling
The Klein laboratory is a molecular medical mycology research group with two broad areas of focus: fungal pathogenesis and immunology.
The overall goal of my laboratory and translational research is the development of targeted therapies and immunotherapies to improve patient survival while reducing short- and long-term side effects from largely untargeted conventional chemotherapies. Currently, my laboratory focuses on three major areas in targeted cancer therapies.