Weixiong Zhong

Focus Groups

Cancer Biology

Signal Transduction

Education

PhD, University of Iowa

MD, Sun Yat-Sen University of Medical Sciences, China

Research Summary

Oxidative stress and redox regulation in carcinogenesis and cancer chemoprevention

Research Detail

My research focuses on studying redox regulation, biomarkers, and signaling pathways for prevention and treatment of cancer. The goals are to identify key proteins and/or signaling pathways in cancer progression and for chemoprevention or targeted therapy.

Selected Publications

Rituximab and Monitoring Strategies for Late Antibody-Mediated Rejection After Kidney Transplantation.Parajuli S, Mandelbrot DA, Muth B, Mohamed M, Garg N, Aziz F, Redfield RR, Zhong W, Astor BC, Djamali A.Transplant Direct. 2017 Oct 27;3(12):e227. doi: 10.1097/TXD.0000000000000746. eCollection 2017 Dec.PMID: 29536028

Extracellular redox state shift: A novel approach to target prostate cancer invasion.Zhong W, Weiss HL, Jayswal RD, Hensley PJ, Downes LM, St Clair DK, Chaiswing L.FreeRadic Biol Med. 2018 Mar;117:99-109. doi: 10.1016/j.freeradbiomed.2018.01.023. Epub 2018 Feb 2.PMID: 29421238

Complete B Cell Deficiency Reduces Allograft Inflammation and Intragraft Macrophages ina Rat Kidney Transplant Model.Panzer SE, Wilson NA, Verhoven BM, Xiang D, Rubinstein CD, Redfield RR, Zhong W, Reese SR.Transplantation. 2018 Mar;102(3):396-405. doi: 10.1097/TP.0000000000002010.PMID: 29215459

Kidney Transplant Recipients With Primary Membranous Glomerulonephritis Have a Higher Risk of Acute Rejection Compared With Other Primary Glomerulonephritides.Singh T, Astor B, Zhong W, Mandelbrot D, Djamali A, Panzer S.Transplant Direct. 2017 Oct 18;3(11):e223. doi: 10.1097/TXD.0000000000000736. eCollection 2017 Nov.PMID: 29184911

Guidelines for the management of a brain death donor in the rhesus macaque: A translational transplant model.Zens TJ, Danobeitia JS, Chlebeck PJ, Zitur LJ, Odorico S, Brunner K, Coonen J, Capuano S, D’Alessandro AM, Matkowskyj K, Zhong W, Torrealba J, Fernandez L.PLoS One. 2017 Sep 19;12(9):e0182552. doi: 10.1371/journal.pone.0182552. eCollection 2017.PMID: 28926566

Loss of Igf2 Gene Imprinting in Murine Prostate Promotes Widespread Neoplastic Growth.Damaschke NA, Yang B, Bhusari S, Avilla M, Zhong W, BluteML Jr, Huang W, Jarrard DF.Cancer Res. 2017 Oct 1;77(19):5236-5247. doi: 10.1158/0008-5472.CAN-16-3089. Epub 2017 Aug 3.PMID: 28775169

Safety and Immunological Efficacy of a DNA Vaccine Encoding the Androgen Receptor Ligand-Binding Domain (AR-LBD).Olson BM, Bradley ES, Sawicki T, Zhong W, Ranheim EA, Bloom JE, Colluru VT, Johnson LE, Rekoske BT, Eickhoff JC, McNeel DG.Prostate. 2017 May;77(7):812-821. doi: 10.1002/pros.23321. Epub 2017 Feb 9.PMID: 28181678

Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance.Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes WJ, Zhong W, Brennan TV, Dutta P, Claas FH, van Rood JJ, Burlingham WJ.Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1099-1104. doi: 10.1073/pnas.1618364114. Epub 2017 Jan 17.PMID: 28096390

Pharmacokinetics and Renal Toxicity of Monomeric Amphotericin B in Ratsafter a Multiple Dose Regimen.Kang JY, Gao J, Shin DH, Alvarez C, Zhong W, Kwon GS.Pharm Nanotechnol. 2016;4(1):16-23.PMID: 27774409

Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer.Hafeez BB, Meske L, Singh A, Singh A, Zhong W, PowersP, John M, Griep AE, VermaAK.Oncotarget. 2016 May 31;7(22):33069-80.doi: 10.18632/oncotarget.8850.PMID: 27102301