Tyler Ulland

Credentials: MS, PhD

Position title: Assistant Professor

Email: tulland@wisc.edu

Phone: 608-263-0832

Address:
MSC 5640
1300 University Ave.
Madison, WI 53706

Lab
Ulland Lab

Focus Groups

Immunology/Immunopathology

Neuroscience/Neuropathology

Education

PhD, Molecular and Cellular Biology (now Molecular Medicine), University of Iowa

MS, Immunology, University of Iowa

Research Summary

The innate immune response to neurodegenerative disease has been understudied until very recently. The Ulland Lab focuses on the role of the innate immune response and more specifically microglial response in AD. We have established the tools and models to effectively work on the neuroimmune response during AD. The ultimate goal of our group is to provide a more thorough understanding of the molecular and metabolic changes in immune cells that precede and follow AD onset, information that will be important in intelligently designing therapeutic strategies.

Research Detail

Research in the Ulland Lab is focused on gaining a deeper understanding of the mechanisms, including metabolic and transcriptional changes, which govern the innate immune response in neurodegeneration with a focus on Alzheimer’s disease (AD). Our interests fall into 4 distinct areas:

  • Defining the role of microglial autophagy and TREM2 signaling in AD.
  • Investigating the role of systemic inflammation on microglia prior to and during AD.
  • Determining the role of microglia in recruiting and influencing the functionality of neutrophils during AD pathogenesis.
  • Examining the effect of different carbohydrate sources on the microglia in 5XFAD and non-5XFAD animals with or without the expression of Trem2.

Ultimately the goal of our research is to inform the design of new therapeutic approaches to AD with a particular focus on targeting and modifying the innate immune response during neurodegeneration.

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