Quaovi Sodji

Education:

MD, Medical College of Georgia

PhD, Georgia Institute of Technology

Research Summary

My laboratory focus is the development of novel cancer therapeutics including immunotherapeutic agents that can be used as monotherapy and/or in combination with radiation therapy and understand the mechanisms of potential synergistic effects.

Research Detail

Radiation delivered by targeted radionuclide therapy (TRT) and chimeric antigen receptor (CAR) T cell therapy are emerging therapies that have revolutionized cancer therapy. However, each of these therapies is confronted by limitations that can potentially be resolved by the other. As such, understanding the mechanisms that govern the interactions between these novel therapies and ways to effectively harness their potential synergism will be crucial for advancing the field of oncology. Following the understanding of the mechanisms of these interactions, I propose the development of modulators including CAR T cell therapy, small molecules, and drug-antibody conjugates capable of effectively harnessing the collaborative effects between TRT and CAR T cells therapy.