Position title: Assistant Professor
Website: Matt Reynolds's website
585 Science Dr, Madison WI 53711
PhD Cellular and Molecular Pathology, University of Wisconsin-Madison
SIV/HIV reservoirs; Antiviral immunity; Monoclonal antibody isolation
My laboratory focuses on developing innovative tools for investigating and combating human diseases. Our primary area of research is evaluating the virologic and immunologic mechanisms that control AIDS virus replication. We have developed a novel model to precisely set the size of latent simian immunodeficiency virus (SIV) reservoirs by infusing defined numbers of in vitro generated latently infected cells into SIV-naive rhesus macaques. With this model, we investigate how latent reservoir size affects an individual’s ability to control virus replication after stopping antiretroviral drug treatment.
Our other research focus is isolating monoclonal antibodies. We developed an efficient method for isolating monoclonal antibodies from memory B cells and employ it to clone antibodies for diagnostic or therapeutic use.