Bo Liu

Focus Groups

Signal Transduction

Education

PhD, Biochemistry, SUNY Downstate

Research Summary

Vascular diseases, cell apoptosis, inflammation, signaling, adult progenitor cells, gene therapy

Research Detail

A major research goal of Liu’s lab is to understand the pathophysiology of vascular disease including atherosclerosis, restenosis (intimal hyperplasia) and abdominal aortic aneurysms. Using a combination of molecular, biochemical and genetic approaches, Dr. Liu and her co-investigators identified several intracellular signaling proteins that are critical in regulation of vascular smooth muscle cells, endothelial cells, fibroblasts and progenitor cells. Current research topics include interaction between smooth muscle cell apoptosis and vascular inflammation, progenitor cell recruitment and differentiation, signaling pathways underlying apoptosis, migration, cytokine expression and other functions of smooth muscle cells. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, who has created a lab environment that fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

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