Position title: Associate Professor
- Department Profile
PhD Pharmacology, Johns Hopkins
Development of targeted diagnostics and therapeutics for prostate cancer and SARS-CoV-2 using novel antibody scaffolds and engineered immune cells.
Aaron LeBeau, PhD is an Associate Professor in the Departments of Radiology and Pathology and Laboratory Medicine. The LeBeau laboratory operates at the interface of synthetic biology and nuclear medicine with the goal is to develop novel antibody-based molecular imaging probes and targeted therapeutics for cancer. The laboratory specializes in antibody phage display, which allows the team to rapidly identify antibody fragments against cancer-associated antigens using the in-house human and mouse antibody libraries. When coupled to radioisotopes, antibodies are employed as positron-emission tomography (PET) and single-emission computed tomography (SPECT) nuclear imaging probes and as radioimmunotherapy agents. The laboratory has also developed non-human single-domain antibody libraries from naïve camelids and nurse sharks that will serve as next-generation antibody-drug conjugates and imaging probes in oncology. In addition to the work in cancer, the LeBeau laboratory has active projects developing non-canonical neutralizing antibodies and imaging probes for beta-coronaviruses including SARS-CoV-2.