Dudley Lamming

Credentials: PhD

Position title: Assistant Professor

Email: dlamming@medicine.wisc.edu

Phone: (608) 256-1901 x12861

Address:
2500 Overlook Terr
VAH C3127 Res 151
Madison, WI 53705

Lab
Lamming Lab

Focus Groups

Cancer Biology

Signal Transduction

Education

PhD, Harvard University

BS, Massachusetts Institute of Technology

Research Summary

The Lamming laboratory’s goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.

Research Detail

The Lamming laboratory’s goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

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