Dudley Lamming
Credentials: PhD
Position title: Associate Professor
Email: dlamming@medicine.wisc.edu
Phone: (608) 256-1901 x12861
Address:
2500 Overlook Terr
VAH C3127 Res 151
Madison, WI 53705
- Lab
- Lamming Lab
Focus Groups
Cancer Biology
Signal Transduction
Education
PhD, Harvard University
BS, Massachusetts Institute of Technology
Research Summary
The Lamming laboratory’s goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
Research Detail
The Lamming laboratory’s goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.