David Kosoff

Credentials: MD

Position title: Assistant Professor

Email: dkosoff1@medicine.wisc.edu

Phone: (608) 263-4690

7105 WIMR 1
1111 Highland Ave
Madison, WI 53705

Department Profile
Department of Medicine


MD – University of Illinois College of Medicine


Translational cancer research, Tumor microenvironment, Novel therapy development and Microfluidic technologies


The Kosoff Lab is focused on developing new therapeutic strategies for cancer treatment. Our primary research interest is the tumor microenvironment (TME), which is the array of non-malignant cells (immune cells, stromal cells, etc.) and stroma that support cancer progression and the development of therapeutic resistance. Our research is aimed at identifying the chemical and mechanical pathways that drive TME-mediated tumor progression and developing therapeutic strategies to target those pathways. This research is supported by a close collaboration with the Biomedical Engineering laboratory of Dr. David Beebe. Together, we have developed novel microfluidic cell culture technologies, which enable advanced modeling and analysis of multi-cellular environments. We have leveraged these microfluidic technologies to investigate various aspects of the TME, including the factors that modulate tumor-directed immune responses, the combined effects of chemical and mechanical stimuli on TME cell phenotype, and the efficacy of TME-directed therapeutic strategies. The members of our lab are continuing to build on this work with the goal of translating our findings into early phase clinical trials.