Matthew Brown

Focus Groups

Immunology/Immunopathology

Education

PhD, Cellular and Molecular Pathology, University of Wisconsin-Madison

Research Summary

The Brown Lab focuses on exploring the nexus of pluripotent stem cell (PSC) biology and immunology.

Research Detail

We are currently investigating the mechanisms underpinning the immune response to autologous and allogeneic PSC-derived cardiovascular cell therapies.  Using transplantation immunology and genomics-based strategies, in conjunction with humanized and primatized mouse models, our goals are to 1) improve traditional solid organ transplantation outcomes, 2) gain new insights into PSC biology and immunology, and 3) enable curative regenerative medicine therapies.

Key lab research tools: flow cytometry, RNA sequencing, cell culture, and CRISPR/Cas9 gene-editing.

Publications

https://www.ncbi.nlm.nih.gov/myncbi/16c6pKkNrc9Q9D/bibliography/public/