Alexander Birbrair

Education

PhD 2014, PhD, Neuroscience, Wake Forest University, North Carolina, USA
2009, BS, Biomedical Sciences, Santa Cruz State University, Bahia, Brazil

Postdoctoral training

Albert Einstein College of Medicine, New York, NY, USA

Research Summary

1) Cancer biology, 2) Tumor microenvironment, 3) Nervous system influences on cancer progression

Research Detail

Our lab is committed to understand the mechanisms of impairment and failure of biological systems under pathological conditions with emphasis on preventing or reversing these deleterious processes. We focus on tissue stem cells, vasculature, and the peripheral nervous system present in different tissues microenvironments. We are interested in studying mechanisms that lead to cell behavior changes during development, throughout life and disease. Understanding how these mechanisms are affected in cancer will help develop targets for novel therapies. For this, we take advantage of state-of-the-art technologies, including two-photon and confocal microscopy, in vivo lineage-tracing methods, FACS-sorting, single-cell RNA sequencing, organ, tissue and cell transplantation, neural circuitry analysis, and sophisticated Cre/loxP techniques in combination with cancer mouse models. Thus, our ultimate goal is to identify novel potential cellular and molecular targets for cancer therapy.

Publications

https://pubmed.ncbi.nlm.nih.gov/?term=Birbrair+A&cauthor_id=36202693