Tim Yoshino
Credentials: PhD
Position title: Professor
Email: yoshinot@svm.vetmed.wisc.edu
Phone: (608) 263-6002
Address:
127 Biotron
2115 Observatory Dr
Madison, WI 53706
Focus Groups
Immunology/Immunopathology
Education
PhD, Biology, University of California, Santa Barbara
Postdoctoral, Institute for Pathobiology, Lehigh University
Research Summary
Molecular Parasitology, Schistosomiasis, Parasite-Host Interactions, Mollusc Intermediate Host, Innate Immunity, Pathogen Recognition Receptors, Glycobiology, Neglected Tropical Diseases
Research Detail
Human schistosomiasis is a neglected tropical disease that results from infection by several species of the parasitic flatworm Schistosoma. My research is focused on defining and characterizing the molecular basis for innate resistance and susceptibility of inbred strains of the snail Biomphalaria glabrata to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis. Methods involving cellular and molecular biology, tissue culture, genomics/proteomics and whole organism manipulations are used to define and characterize the innate immune system of the snail host, in order to gain a better understanding of the underlying processes regulating immune resistance to schistosome larval infection.