Andreas Friedl
Credentials: MD
Position title: Professor
Email: afriedl@wisc.edu
Phone: (608) 265-9283
Address:
6051 WIMR
1111 Highland Ave
Madison, WI 53705
Focus Groups
Cancer Biology
Signal Transduction
Education
Dr. of Medicine (Dr. med.), University of Erlangen, Germany
MD, University of Erlangen, Germany
Research Summary
Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Research Detail
My research focuses on the role of heparan sulfate proteoglycans (HSPGs) in tumorigenesis and cancer progression. HSPGs are hybrid molecules, which consist of core proteins and heparin-like polysaccharide domains. HSPGs are found in abundance on cell surfaces and in the extracellular matrix. One project focuses on the role of the HSPG syndecan-1 in stromal fibroblasts of breast carcinomas. The goal is to decipher the mechanisms by which stromal syndecan-1 stimulates breast carcinoma growth and invasion. A separate project aims at identifying the mechanisms by which the HSPG glypican-1 regulates cell cycle progression in brain tumor cells.