My research focuses on studying redox regulation, biomarkers, and signaling pathways for prevention and treatment of cancer. The goals are to identify key proteins and/or signaling pathways in cancer progression and for chemoprevention or targeted therapy.
Weixiong Zhong, MD, PhD
Pathology and Laboratory Medicine
600 Highland Ave
Madison, WI 53792
PhD, University of Iowa
MD, Sun Yat-Sen University of Medical Sciences, China
Oxidative stress and redox regulation in carcinogenesis and cancer chemoprevention
Chaiswing L, Zhong W, Oberley TD. Increasing discordant antioxidant protein levels and enzymatic activities contribute to increasing redox imbalance observed during human prostate cancer progression. Free Radic Biol Med 67:342-352, 2014.
Teoh-Fitzgerald ML, Fitzgerald MP, Zhong W, Askeland RW, Domann FE. Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis. Oncogene 33:358-368, 2014.
Jorgenson TC, Zhong W, Oberley TD. Redox imbalance and biochemical changes in cancer. Cancer Res 73:6118-6123, 2013.
Chaiswing L, Zhong W, Liang Y, Jones DP, Oberley TD. Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance. Free Radic Biol Med 52:452-61, 2012.
Hafeez BB, Zhong W, Weichert J, Dreckschmidt NE, Jamal MS, Verma AK. Genetic ablation of PKC Epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res 71:2318-2327, 2011.
Shan W, Zhong W, Zhao R, Oberley TD. Thioredixin 1 as a subcellular biomarker of redox imbalance in human prostate cancer progression. Free Radic Biol Med 49:2078-2087, 2010.
Xiang N, Zhao R, Song G, Zhong W. Selenite Reactivates Silenced Genes by Modifying DNA Methylation and Histones in Prostate Cancer Cells. Carcinog 29:2175-2181, 2008.
Chaiswing L, Zhong W, Joseph J. Cullen, Larry W. Oberley, Oberley TD Extracellular redox state of prostate cancer cells regulates features related to aggressive behavior. Cancer Res 68:5820-5826, 2008.
Zhao R, Xiang N, Domann RE, and Zhong W. Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Res 66:2296-2304, 2006.
Zhong W and Oberley TD. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cells. Cancer Res 61:7071-7078, 2001.