Thomas C. Friedrich, PhD

Portrait of Thomas C. Friedrich, PhD
Associate Professor
Pathobiological Sciences
Rm 127 555 Science Dr
555 Science Dr
Madison, WI 53711
(608) 265-3381
Focus Groups: 
PhD, University of Wisconsin
Research Summary: 
Viral immunity; pathogenesis
Research Detail: 

Why do we get sick? This simple question underpins all research in my laboratory. Our overarching goal is to understand why immune responses sometimes fail to protect us from acute and chronic viral diseases. We study innate and adaptive immune responses to acute and chronic viral infections and the mechanisms viruses have evolved to subvert them. Through our discoveries, we hope to contribute to the global campaigns against pandemic influenza and AIDS.

Our work focuses on immune responses to viral infection in nonhuman primates. Because monkeys' physiology, genetics, and immune systems so closely resemble our own, they provide the best possible approximation of human infections. My lab is affiliated with the Wisconsin National Primate Research Center, which provides expert veterinary care and support for the nonhuman primates used in research on campus.

Current research topics include:

  • Determining the contribution of cellular immunity to protection against newly emerging influenza viruses in humans and animal models
  • Understanding immune correlates of "elite control" of immunodeficiency virus infection
  • Identifying novel primate viruses in Africa and assessing their pandemic potential
Selected Publications: 
Weinfurter, J.T., G.E. May, T. Soma, A.J. Hessell, E.J. Leon, C.E. Mac Nair, S.M. Piaskowski, K. Weisgrau, J. Furlott, N.J. Maness, J. Reed, N.A. Wilson, E.G. Rakasz, D.R. Burton, and T.C. Friedrich. 2011. Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus. J Virol. 85:530-541.
Lauck, M., D. Hyeroba, A. Tumukunde, G. Weny, S.M. Lank, C.A. Chapman, D.H. O'Connor, T.C. Friedrich, and T.L. Goldberg. 2011. Novel, divergent simian hemorrhagic Fever viruses in a wild ugandan red colobus monkey discovered using direct pyrosequencing. PLoS One. 6:e19056. PMC3081318
O'Connor, S.L., J.J. Lhost, E.A. Becker, A.M. Detmer, R.C. Johnson, C.E. Macnair, R.W. Wiseman, J.A. Karl, J.M. Greene, B.J. Burwitz, B.N. Bimber, S.M. Lank, J.J. Tuscher, E.T. Mee, N.J. Rose, R.C. Desrosiers, A.L. Hughes, T.C. Friedrich, M. Carrington, and D.H. O'Connor. 2010. MHC heterozygote advantage in simian immunodeficiency virus-infected mauritian cynomolgus macaques. Sci Transl Med. 2:22ra18. PMC2865159
Greene, J.M., J.J. Lhost, B.J. Burwitz, M.L. Budde, C.E. Macnair, M.K. Weiker, E. Gostick, T.C. Friedrich, K.W. Broman, D.A. Price, S.L. O'Connor, and D.H. O'Connor. 2010. Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239∆nef-vaccinated macaques suppress SIVmac239 replication ex vivo. J Virol. 84:3362-3372. PMC2838091
Friedrich, T.C., S.M. Piaskowski, E.J. Leon, J.R. Furlott, N.J. Maness, K.L. Weisgrau, C.E. Mac Nair, A.M. Weiler, J.T. Loffredo, M.R. Reynolds, K.Y. Williams, Y.C. Klimentidis, N.A. Wilson, D.B. Allison, and E.G. Rakasz. 2010. High viremia is associated with high levels of in vivo major histocompatibility complex class I downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239. J Virol. 84:5443-5447. PMC2863841
Sacha, J.B., J.P. Giraldo-Vela, M.B. Buechler, M.A. Martins, N.J. Maness, C. Chung, L.T. Wallace, E.J. Leon, T.C. Friedrich, N.A. Wilson, A. Hiraoka, and D.I. Watkins. 2009. Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection. Proc Natl Acad Sci U S A. 106:9791-9796. PMC2687996
Wilson, N.A., B.F. Keele, J.S. Reed, S.M. Piaskowski, C.E. MacNair, A.J. Bett, X. Liang, F. Wang, E. Thoryk, G.J. Heidecker, M.P. Citron, L. Huang, J. Lin, S. Vitelli, C.D. Ahn, M. Kaizu, N.J. Maness, M.R. Reynolds, T.C. Friedrich, J.T. Loffredo, E.G. Rakasz, S. Erickson, D.B. Allison, M.J. Piatak, J.D. Lifson, J.W. Shiver, D.R. Casimiro, G.M. Shaw, B.H. Hahn, and D.I. Watkins. 2009. Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge. J Virol. 83:6508-6521. PMC2698536
Friedrich, T.C., and D.I. Watkins. 2008. Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus. Curr Opin HIV AIDS. 3:393-398.
Sacha, J.B., C. Chung, E.G. Rakasz, S.P. Spencer, A.K. Jonas, A.T. Bean, W. Lee, B.J. Burwitz, J.J. Stephany, J.T. Loffredo, D.B. Allison, S. Adnan, A. Hoji, N.A. Wilson, T.C. Friedrich, J.D. Lifson, O.O. Yang, and D.I. Watkins. 2007. Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression. J Immunol. 178:2746-2754.
Friedrich, T.C., L.E. Valentine, L.J. Yant, E.G. Rakasz, S.M. Piaskowski, J.R. Furlott, K.L. Weisgrau, B. Burwitz, G.E. May, E.J. Leon, T. Soma, G. Napoe, S.V.r. Capuano, N.A. Wilson, and D.I. Watkins. 2007. Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication. J Virol. 81:3465-3476. PMC1866056