Thaddeus Golos, MS, PhD

Portrait of Thaddeus Golos, MS, PhD
Comparative Biosciences
115 Wisconsin Primate Center
1223 Capitol Ct
Madison, WI 53715
(608) 263-3567; (608) 263-3537
Focus Groups: 
PhD, Physiology, University of Illinois at Urbana-Champaign
MS, Physiology, University of Illinois at Urbana-Champaign
Research Summary: 
Placental and endometrial biology, the maternal-fetal interface in health and disease, nonhuman primate embryology and genetic modification for human disease models.
Research Detail: 

The Golos lab has pioneered the use of the nonhuman primate model in reproductive immunology and the placental expression and regulation of nonclassical MHC class I molecules. Study of the maternal-fetal immune dialogue includes nonpolymorphic MHC class I molecules expression on placental cells and their interactions with the maternal immune system, particularly endometrial natural killer cells and macrophages in promoting pregnancy success, including effects on placental and endometrial differentiation and vascularization. Recent studies have developed models with immune-mediated pregnancy loss and placental insufficiency in the rhesus. The impact of bacterial pathogens on pregnancy utilizes nonhuman primate in vivo Listeria monocytogenes and Porphyromonas gingivalis infection. He is collaborating with colleagues in Ob-Gyn and Medical Physics to apply magnetic resonance imaging methodologies to primate models of inflammation and adverse pregnancy outcomes. In addition, a multifaceted team of investigators at UW-Madison are conducting a range of studies of Zika virus infection in nonhuman primates, and the Golos lab is leading study of Zika-infected pregnancies in the rhesus model.


Previous experience with nonhuman primate in vitro fertilization is also being used to develop novel models of human disease through iPSC generation, transgenesis,  and genomic editing, as well as to study Zika virus sexual transmission and impact on fertility and embryonic development.

Selected Publications: 
The Critical Role of Nonhuman Primates in Medical Research. Friedman H, Ator N, Haigwood N, Newsome W, Allan JS, Golos TG, Kordower JH, Shade RE, Goldberg ME, Bailey MR, Bianchi P. Pathog Immun. 2017;2(3):352-365. doi: 10.20411/pai.v2i3.186. PMID: 29034361
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. Vermilyea SC, Guthrie S, Meyer M, Smuga-Otto K, Braun K, Howden S, Thomson JA, Zhang SC, Emborg ME, Golos TG. Stem Cells Dev. 2017 Sep 1;26(17):1225-1235. doi: 10.1089/scd.2017.0069. PMID: 28635509
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network. Aliota MT, Bassit L, Bradrick SS, Cox B, Garcia-Blanco MA, Gavegnano C, Friedrich TC, Golos TG, Griffin DE, Haddow AD, Kallas EG, Kitron U, Lecuit M, Magnani DM, Marrs C, Mercer N, McSweegan E, Ng LFP, O'Connor DH, Osorio JE, Ribeiro GS, Ricciardi M, Rossi SL, Saade G, Schinazi RF, Schott-Lerner GO, Shan C, Shi PY, Watkins DI, Vasilakis N, Weaver SC. Antiviral Res. 2017 Aug;144:223-246. doi: 10.1016/j.antiviral.2017.06.001. Review. PMID: 28595824
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. Nguyen SM, Antony KM, Dudley DM, Kohn S, Simmons HA, Wolfe B, Salamat MS, Teixeira LBC, Wiepz GJ, Thoong TH, Aliota MT, Weiler AM, Barry GL, Weisgrau KL, Vosler LJ, Mohns MS, Breitbach ME, Stewart LM, Rasheed MN, Newman CM, Graham ME, Wieben OE, Turski PA, Johnson KM, Post J, Hayes JM, Schultz-Darken N, Schotzko ML, Eudailey JA, Permar SR, Rakasz EG, Mohr EL, Capuano S 3rd, Tarantal AF, Osorio JE, O'Connor SL, Friedrich TC, O'Connor DH, Golos TG. PLoS Pathog. 2017 May 25;13(5):e1006378. doi: 10.1371/journal.ppat.1006378. PMID: 28542585
Porphyromonas gingivalis and adverse pregnancy outcome. Reyes L, Philips P, Wolfe B, Golos T, Walkenhorst M, Progulski-Fox A, Brown M. 2017. Journal of Oral Microbiology 0038R1.
Hofbauer Cells: Placental Macrophages of Fetal Origin. Reyes L, Wolfe B, Golos T. Results Probl Cell Differ. 2017;62:45-60. doi: 10.1007/978-3-319-54090-0_3. Review. PMID: 28455705
Acute Fetal Demise with First Trimester Maternal Infection Resulting from Listeria monocytogenes in a Nonhuman Primate Model. Wolfe B, Wiepz GJ, Schotzko M, Bondarenko GI, Durning M, Simmons HA, Mejia A, Faith NG, Sampene E, Suresh M, Kathariou S, Czuprynski CJ, Golos TG. MBio. 2017 Feb 21;8(1). pii: e01938-16. doi: 10.1128/mBio.01938-16. PMID: 28223455
Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases. Kropp J, Di Marzo A, Golos T. Biol Reprod. 2017 Feb 1;96(2):277-287. doi: 10.1095/biolreprod.116.146514. PMID: 28203717
Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques. Aliota MT, Dudley DM, Newman CM, Mohr EL, Gellerup DD, Breitbach ME, Buechler CR, Rasheed MN, Mohns MS, Weiler AM, Barry GL, Weisgrau KL, Eudailey JA, Rakasz EG, Vosler LJ, Post J, Capuano S 3rd, Golos TG, Permar SR, Osorio JE, Friedrich TC, O'Connor SL, O'Connor DH. PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005168. doi: 10.1371/journal.pntd.0005168. PMID: 27911897
Macrophages modulate the growth and differentiation of rhesus monkey embryonic trophoblasts. Rozner AE, Durning M, Kropp J, Wiepz GJ, Golos TG. Am J Reprod Immunol. 2016 Nov;76(5):364-375. doi: 10.1111/aji.12564. PMID: 27637575
A rhesus macaque model of Asian-lineage Zika virus infection. Dudley DM, Aliota MT, Mohr EL, Weiler AM, Lehrer-Brey G, Weisgrau KL, Mohns MS, Breitbach ME, Rasheed MN, Newman CM, Gellerup DD, Moncla LH, Post J, Schultz-Darken N, Schotzko ML, Hayes JM, Eudailey JA, Moody MA, Permar SR, O'Connor SL, Rakasz EG, Simmons HA, Capuano S, Golos TG, Osorio JE, Friedrich TC, O'Connor DH. Nat Commun. 2016 Jun 28;7:12204. doi: 10.1038/ncomms12204. PMID: 27352279
Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Prabhudas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune J, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga, K. 2015. Nat. Immunol. 16: 328-34.