Shelby O'Connor, PhD

Portrait of Shelby O'Connor, PhD
Assistant Professor
Pathology and Laboratory Medicine
585 Science Dr
Madison, WI 53711
(608) 890-0843
Focus Groups: 
PhD, Cellular and Molecular Biology, UW-Madison
Research Summary: 
Host and vaccine-elicited immune responses to SIV/HIV; Changes to SIV/HIV host immune responses during co-infection with a second pathogen
Research Detail: 

SIV pathogenesis and vaccine projects: We are interested in improving the immune response to SIV/HIV in someone who is already infected.  To do this, we are exploring how immunomodulatory agents can boost antiviral immunity and suppress virus replication.   

SIV/Mtb co-infection studies: HIV+ individuals rapidly become sick after co-infection with secondary pathogens, such as Mycobacterium tuberculosis (Mtb). We are interested in understanding why HIV+ immunocomprimised individuals are unable to control bacterial replication. We hope these studies will help identify critical therapeutic interventions to prevent HIV+ individuals from becoming sick with tuberculosis.

Selected Publications: 
Gellerup, D., A. Balgeman, C. W. Nelson, A. Ericsen, M. Scarlotta, A. L. Hughes, and S. O’Connor. 2015. Conditional immune escape during chronic SIV infection. J Virol. 90: 545-52. PMC4702533. 26491171.
Sutton, M.S., Burns, C.M., Weiler, A.M., Balgeman, A.J., Braasch, A.T., Lehrer-Brey, G., Friedrich, T.C., and O'Connor, S.L. 2016. Vaccination with live attenuated SIV protects from mucosal, but not necessarily intravenous, challenge with a minimally heterologous SIV. J Virol. PMC Journal -- in process. 26962218.
Harris, M.*, Burns, C.M.*, Becker, E.A., Braasch, A.T., Gostick, E., Johnson, R.C., Broman, K.W., Price, D.A., Friedrich, T.C., and O'Connor, S.L. Acute CD8 T cell responses that select for escape variants are needed to control live attenuated SIV. (2013) Journal of Virology. In Press.
O'Connor, S.L., Becker, E.A., Weinfurter, J.T., Chin, E.N., Budde, M.L., Gostick, E., Correll, M. Gleicher, M. Hughes, A.L., Price, D.A., Friedrich, T.C., and O'Connor, D.H. (2012) Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. J Virol. 86(1): 605-609.
Budde, M.L.*, Greene, J.M.*, Chin, E.N., Ericsen, A.J., Scarlotta, M., Cain, B.T., Pham, N.H., Becker, E.A., Harris, M., Weinfurter, J.T., O'Connor, S.L, Piatak, M. Jr, Lifson, J.D., Gostick, E., Price, D.A., Friedrich, T.C., and O'Connor, D.H. (2012) Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques. J Virol 86(14): 7596-604.
Becker, E.A., Burns, C.M., Leon, E.J., Rajabojan, S., Friedman, R., Friedrich, T.C., O'Connor, S.L., and Hughes, A.L. (2012) Experimental analysis of sources of error in evolutionary studies based on Roche/454 pyrosequencing of viral genomes. Genome Biol Evol 4(4): 457-465.
Hughes, A.L., Becker, E.A., Lauck, M., Karl, J.A., Braasch, A.T., O'Connor, D.H., and O'Connor, S.L. (2012) SIV Genome-wide Pyrosequencing Provides a Comprehensive and Unbiased View of Variation within and outside CD8 T Lymphocyte Epitopes. PLoS One 7(10): e47818.
O’Connor, S.L., Lhost, J.J., Becker, E.A., Detmer, A.M., Johnson, R.C., MacNair, C.E., Wiseman, R.W., Karl, J.A., Greene, J.M., Burwitz, B.J., Bimber, B.N., Lank, S.M., Tuscher, J.J., Mee, E.T., Rose, N.J., Desrosiers, R.C., Hughes, A.L., Friedrich, T.C., Carrington, M., and O’Connor, D.H. (2010) MHC Heterozygote Advantage in Simian Immunodeficiency Virus-Infected Mauritian Cynomolgus Macaques. Sci Transl Med. 2: 22ra18.