Ricardo V. Lloyd, MD, PhD

Portrait of Ricardo V. Lloyd, MD, PhD
Pathology and Laboratory Medicine
8550, K4/436 CSC
600 Highland Avenue
Madison, WI 53792
(608) 265-4377
Focus Groups: 
Cancer Biology
MD, University of Wisconsin, Madison
PhD, University of Wisconsin, Madison
Postdoctoral, Memorial Sloan Kettering Cancer Center
Research Summary: 
Thyroid cancer stem cells, Neuroendocrine tumors, Pituitary tumors
Research Detail: 

We use multiple approaches to understand the biological and functional significance of thyroid cancer stem cells, the regulatory role of transforming growth factor beta and microRNA expression in these cancer stem cells. We also study other neuroendocrine tumors such as intestinal carcinoid and pancreatic neuroendocrine tumors and pituitary tumors. Our overall goal is to characterize the biological features of cancer stem cells and their regulation in order to develop more effective therapies for highly lethal endocrine cancers. 

No room for a student

Selected Publications: 
Generation of Novel Thyroid Cancer Stem-Like Cell Clones: Effects of Resveratrol and Valproic Acid. Hardin H, Yu XM, Harrison AD, Larrain C, Zhang R, Chen J, Chen H, Lloyd RV. Am J Pathol. 2016 Jun;186(6):1662-73. doi: 10.1016/j.ajpath.2016.02.003. Epub 2016 Apr 7. PMID: 27060227
Non-Coding RNAs in Thyroid Cancer. Zhang R, Hardin H, Chen J, Guo Z, Lloyd RV. Endocr Pathol. 2016 Mar;27(1):12-20. doi: 10.1007/s12022-016-9417-8. PMID: 26847830
INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms. Rosenbaum JN, Guo Z, Baus RM, Werner H, Rehrauer WM, Lloyd RV. Am J Clin Pathol. 2015 Oct;144(4):579-91. doi: 10.1309/AJCPGZWXXBSNL4VD. PMID: 26386079
Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. Starenki D, Hong SK, Lloyd RV, Park JI. Oncogene. 2015 Aug 27;34(35):4624-34. doi: 10.1038/onc.2014.392. Epub 2014 Dec 1. PMID: 25435367
The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu XM, Harrison AD, Chen H, Lloyd RV. Am J Pathol. 2014 Aug;184(8):2342-54. doi: 10.1016/j.ajpath.2014.04.011. Epub 2014 Jun 17. PMID: 24946010
Cancer stem-like cells and thyroid cancer. Guo Z, Hardin H, Lloyd RV. Endocr Relat Cancer. 2014 Oct;21(5):T285-300. doi: 10.1530/ERC-14-0002. Epub 2014 Apr 30. Review. PMID: 24788702
Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers. Hardin H, Montemayor-Garcia C, Lloyd RV. Hum Pathol. 2013 Sep;44(9):1707-13. doi: 10.1016/j.humpath.2013.01.009. Epub 2013 Mar 22. PMID: 23528862
Lloyd RV, Hardin H, Montemayor-Garcia C, et al. "Stem cells and cancer stem-like cells in endocrine tissues." Endocr. Pathol.. 2013;24(1):1-10.
Buehler D, Hardin H, Shan W, et al. "Expression of epithelial-mesenchymal transition regulators SNAI2 and TWIST1 in thyroid carcinomas." Mod. Pathol.. 2013;26(1):54-61.
Gilbert JA, Adhikari LJ, Lloyd RV, Halfdanarson TR, Muders MH, Ames MM. "Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors." Pancreas. 2013;42(3):411-21.
Murray SE Sippel RS Lloyd R Chen H. Surveillance of Small Rectal Carcinoid Tumors in the Absence of Metastatic Disease. Ann Surg Oncol. 2012 Jun 16.
Lloyd RV Buehler D Khanafshar E . Papillary thyroid carcinoma variants. Head Neck Pathol. 2011 Mar;5(1):51-6.
Lloyd RV. Adrenal cortical tumors, pheochromocytomas and paragangliomas. Mod Pathol. 2011 Apr;24 Suppl 2:S58-65.
Ruebel KH, Leontovich AA, Stilling GA, Zhang S, Rishi A, Jin L, Lloyd RV. (2010) Micro RNA expression in ileal carcinoid tumors: down regulation of micro RNA-133a with tumor progression. Modern Pathology 23, 367-375. PMIC2886953
Gilbert JA, Adhikari LJ, Lloyd RV, Rubin J, Haluska P, Carboni JM, Gottardis MM, Ames MM. (2010) Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors. Endocr Relat Cancer 25:623-36.
Chen H Sippel RS O'Dorisio MS Vinik AI Lloyd RV Pacak K . The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas. 2010 Aug;39(6):775-83.
Lloyd RV, Erickson LA, Asioli S. Papillary Thyroid Carcinoma With Prominent Hobnail Features: A New Aggressive Variant of Moderately Differentiated Papillary Carcinoma. A Clinicopathologic, Immunohistochemical, and Molecular Study of 8 Cases. Am J Surg Pathol. 2010 May 3