Peiman Hematti, MD

Portrait of Peiman Hematti, MD
4033 WIMR
1111 Highland Ave
Madison, WI 53705
(608) 265-0106
Focus Groups: 
MD, Tehran University, Iran
Residency, Cleveland Clinic Foundation, Cleveland, OH
Hematology Fellowship and Postdoctoral, NHLBI, NIH, Bethesda, MD
Research Summary: 
Bone marrow stem cell biology
Research Detail: 

Peiman Hematti, MD is Professor of Medicine in section of Hematology/Oncology, UW-Madison School of Medicine and Public Health, with joint appointments in departments of pediatrics, surgery and biomedical engineering. He is director of Clinical Hematopoietic Cell Processing Laboratory, and medical director of Hematopoietic Cell Collection facility at University of Wisconsin_Madison, overseeing bone marrow and stem cell collections, and clinical processing procedures for hematopoietic cell transplantation or other cellular therapy applications at UW-Madison Hospital and Clinics. In addition to participating in clinical care of bone marrow stem cell transplant patients Dr. Hematti is a collaborator on many novel cellular therapy clinical trials. His clinical research interest is in the prevention and treatment of graft versus host disease and other post-transplant immunological complications, novel cellular therapies for cancer treatment, and use of bone marrow stem cells in regenerative medicine.

Dr. Hematti's laboratory research focuses on immunobiology of stem cell transplantation with a special focus on investigating the immunomodulatory and anti-inflammatory properties of macrophages. He is collaborating with many investigators on the UW-campus studying the potential of cellular therapy in many different pre-clinical models.

Selected Publications: 
Hanson SE, Kleinbeck KR, Cantu D, Kim J, Faucher LD, Kao WJ, Hematti P. Local delivery of allogeneic bone marrow and adipose tissue derived mesenchymal stromal cells for cutaneous wound healing in a porcine model. Journal of Tissue Engineering and Regenerative Medicine 2013.
Kim J, Zanjani ED, Jeanblanc CM, Goodrich AD, Hematti P. Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model. Experimental Hematology 2013.
Kim J, Breunig MJ, Escalante LE, Bhatia N, Denu RA, Dollar BA, Stein AP, Hanson SE, Naderi N, Radek J, Haughy D, Bloom DD, Assadi-Porter FM, Hematti P. Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets. Cytotherapy. 2012.
Kim J, Denu RA, Dollar BA, Escalante LE, Kuether JP, Callander NS, Asimakopoulos F, Hematti P. Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol. 2012.
Hanson SE, King, SN, Kim J, Chen X, Thibeault SL, Hematti P. The effect of mesenchymal stromal cell – hyaluronic acid hydrogel constructs on immunophenotype of macrophages. Tissue Engineering Part A 2011.
Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol 37(12):1445-53, 2009.
Trivedi P, Hematti P. Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cells. Exp Hematol 36(3):350-9, 2008.