Peiman Hematti, MD

Portrait of Peiman Hematti, MD
4033 WIMR
1111 Highland Ave
Madison, WI 53705
(608) 265-0106
Focus Groups: 
MD, Tehran University, Iran
Residency, Cleveland Clinic Foundation, Cleveland, OH
Hematology Fellowship and Postdoctoral, NHLBI, NIH, Bethesda, MD
Research Summary: 
Immunobiology of mesenchymal stem cells derived from adult human tissues and human embryonic stem cells; investigating the potential of mesenchymal stem cells in cancer biology, regenerative medicine and transplantation with special a focus on their interactions with macrophages.
Research Detail: 

Dr. Hematti's translational research is on use of novel cell therapies for treatment of a wide range of human disorders. His laboratory research focuses on investigating the immunomodulatory and anti-inflammatory properties of mesenchymal stem cells derived from adult tissues and also from human embryonic stem cells. He is collaborating with many investigators on the UW-campus studying the potential of these cells in stem cell transplantation and regenerative medicine. He is also studying the role of these cells in microenvironment of bone marrow cancer.

Selected Publications: 
Hanson SE, Kleinbeck KR, Cantu D, Kim J, Faucher LD, Kao WJ, Hematti P. Local delivery of allogeneic bone marrow and adipose tissue derived mesenchymal stromal cells for cutaneous wound healing in a porcine model. Journal of Tissue Engineering and Regenerative Medicine 2013.
Kim J, Zanjani ED, Jeanblanc CM, Goodrich AD, Hematti P. Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model. Experimental Hematology 2013.
Kim J, Breunig MJ, Escalante LE, Bhatia N, Denu RA, Dollar BA, Stein AP, Hanson SE, Naderi N, Radek J, Haughy D, Bloom DD, Assadi-Porter FM, Hematti P. Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets. Cytotherapy. 2012.
Kim J, Denu RA, Dollar BA, Escalante LE, Kuether JP, Callander NS, Asimakopoulos F, Hematti P. Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol. 2012.
Hanson SE, King, SN, Kim J, Chen X, Thibeault SL, Hematti P. The effect of mesenchymal stromal cell – hyaluronic acid hydrogel constructs on immunophenotype of macrophages. Tissue Engineering Part A 2011.
Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol 37(12):1445-53, 2009.
Trivedi P, Hematti P. Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cells. Exp Hematol 36(3):350-9, 2008.