Dr. Kimple leads a multi-level research team whose focus is on understanding how the beta-cells of the pancreas respond to nutrient and hormonal stimulation to affect biological changes. Her group is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis of type 1 and type 2 diabetes and in translating these insights into new and improved diabetes therapeutics. Dr. Kimple's research has been funded almost continuously from her PhD onwards by the National Institutes of Health and the Juvenile Diabetes Research Foundation, among other agencies. Her work has been featured in several university press releases and patent applications. Dr. Kimple has been the recipient of several awards, including a Preparing Future Faculty Fellowship from Duke University, where she learned the skills necessary to be a successful mentor and teacher while maintaining a top-tier research laboratory.
Michelle E. Kimple, PhD
2500 Overlook Terrace
Madison, WI 53792
(608) 256-1901 x12861
PhD, Biochemistry & Biophysics, University of North Carolina-Chapel Hill
Postdoctoral,Pharmacology & Cancer Biology, Duke University
Guanine Nucleotide Binding Proteins, pancreatic beta-cell biology, insulin secretion, diabetes pathophysiology
Kimple, M.E., Moss, J.L., Brar, H.K., Rosa, T., Pasker, R.L., Truchan, N.A., Newgard, C.B., and Casey, P.J. (2012). (Deletion of Gαz protects against diet-induced glucose intolerance via expansion of β-cell mass). Journal of Biological Chemistry 2012 Jun 8;287(24):20344-55.
Kelly, P., Bailey, C.L., Fueger, P.T., Newgard, C.B., Casey, P.J., and Kimple, M.E. (2010) (Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation). Journal of Biological Chemistry 285, 15777-85.
Kimple, M.E. , Joseph, J.W., Bailey, C.L., Fueger, P.T., Hendry, I.A., Newgard, C.B., and Casey, P.J. (2008).(Gαz negatively regulates insulin secretion and glucose clearance). Journal of Biological Chemistry 283, 4560-7.
Pagliarini, D.J., Wiley, S.E., Kimple, M.E. , Dixon, J.R., Kelly, P., Casey, P.J., and Dixon, J.E. (2005). (Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells). Molecular Cell 19, 197-207.
Kimple, M.E. , Nixon, A.B., Kelly, P., Bailey, C.L, Young, K.H., Fields, T.A., and Casey, P.J. (2005). (A role for Gz in pancreatic islet beta-cell biology). Journal of Biological Chemistry 280, 31708-31713.
Kimple, R.J., Kimple, M.E. , Betts, L., Sondek, J., and Siderovski, D.P. (2002). (Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits). Nature 416, 878-881.
Kimple, M.E. , Siderovski, D.P., and Sondek, J. (2001).(Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA). EMBO Journal 20, 4414-4422.