Matyas Sandor, PhD

Portrait of Matyas Sandor, PhD
Professor
Pathology and Laboratory Medicine
Address: 
5468 MSC
1300 University Ave
Madison, WI 53706
Telephone: 
(608) 265-8715
Focus Groups: 
Immunology/Immunopathology
Education: 
PhD, L. Eotvos University of Sciences
Research Summary: 
Immune responses to infectious disease
Research Detail: 
  1. Develop novel treatments for controlling latent mycobacterial infections: Tuberculosis is a persistent disease effecting one third of the world’s population. My laboratory developed an innovative acute and novel latency models for in which the role of granulomas in controlling the persistence and reactivation of mycobacterial infection can be studied. We made key discoveries to understand the intriguing relationship between the environment of the host and the pathogen that regulates persistence and reactivation of mycobacteria. My goal is to develop novel cures for controlling latent mycobacterial infections. I have been supported by the Gates Foundation and the NIH to conduct these studies.
  2. To understand the protective and pathologic role of T cells in chronic infections The research in my lab focuses on how elements of the immune response help or harm the host during chronic infection. Chronic inflammation is part of the pathology of many infectious, autoimmune, and neoplastic diseases. Activated T cells are present in most chronic lesions and their cytokine production defines the character and outcome of local inflammatory reactions. Depending upon the disease, disease clearance can be facilitated by either blockage or enhancement of local T cells. My laboratory’s model of chronic inflammation is the infection-induced granulomatous reaction. This localized inflammatory response is important for controlling the growth and dissemination of infectious agents (i.e. intracellular bacteria, parasites and fungi), but the reaction is also part of the disease pathology. Using gene and protein arrays we identified and characterize molecules that regulate acute-chronic granuloma. The dynamic formation and maintenance of granulomatous lesion requires continuous cellular and bacterial traffic into and from these lesions. Supported by an NIH grant we have developed methods to study cell traffic in granulomas using cell type and bacteria specific fluorescent color codes and quantitative PCR for the different fluorescent proteins.
Selected Publications: 
Harris MG, Hulseberg P, Ling C, Karman J, Clarkson BD, Harding JS, et al. Immune privilege of the CNS is not the consequence of limited antigen sampling. Scientific reports. 2014;4:4422. doi: 10.1038/srep04422. PubMed PMID: 24651727; PubMed Central PMCID: PMC3961746.
Clarkson BD, Ling C, Shi Y, Harris MG, Rayasam A, Sun D, et al. T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. The Journal of experimental medicine. 2014;211(4):595-604. doi: 10.1084/jem.20131377. PubMed PMID: 24616379; PubMed Central PMCID: PMC3978271.
Harding JS, Schreiber HA, Sandor M. Granuloma transplantation: an approach to study mycobacterium-host interactions. Frontiers in microbiology. 2011;2:245. doi: 10.3389/fmicb.2011.00245. PubMed PMID: 22180751; PubMed Central PMCID: PMC3235768.
Kiss R, Sandor M, Gere A, Schmidt E, Balogh GT, Kiss B, et al. Discovery of novel histamine H4 and serotonin transporter ligands using the topological feature tree descriptor. Journal of chemical information and modeling. 2012;52(1):233-42. doi: 10.1021/ci2004972. PubMed PMID: 22168379.
Schreiber HA, Harding JS, Altamirano CJ, Hunt O, Hulseberg PD, Fabry Z, et al. Continuous Repopulation of Lymphocyte Subsets in Transplanted Mycobacterial Granulomas. European journal of microbiology & immunology. 2011;1(1):59-69. doi: 10.1556/EuJMI.1.2011.1.8. PubMed PMID: 22096617; PubMed Central PMCID: PMC3215294.
Carrithers LM, Hulseberg P, Sandor M, Carrithers MD. The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations. FEMS immunology and medical microbiology. 2011;63(3):319-27. doi: 10.1111/j.1574-695X.2011.00853.x. PubMed PMID: 22092558.
Clarkson BD, Heninger E, Harris MG, Lee J, Sandor M, Fabry Z. Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS. Advances in experimental medicine and biology. 2012;946:309-33. doi: 10.1007/978-1-4614-0106-3_18. PubMed PMID: 21948376; PubMed Central PMCID: PMC3666851.
Schreiber HA, Sandor M. Monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection. Advances in experimental medicine and biology. 2012;946:277-93. doi: 10.1007/978-1-4614-0106-3_16. PubMed PMID: 21948374.
Schreiber HA, Harding JS, Hunt O, Altamirano CJ, Hulseberg PD, Stewart D, et al. Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice. The Journal of clinical investigation. 2011;121(10):3902-13. doi: 10.1172/JCI45113. PubMed PMID: 21911937; PubMed Central PMCID: PMC3195456.
Vojnov L, Bean AT, Peterson EJ, Chiuchiolo MJ, Sacha JB, Denes FS, et al. DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4(+) T cells, but few subdominant epitope-specific CD8(+) T cells. Vaccine. 2011;29(43):7483-90. doi: 10.1016/j.vaccine.2011.07.048. PubMed PMID: 21839132; PubMed Central PMCID: PMC3186839.
Stolberg VR, Chiu BC, Schmidt BM, Kunkel SL, Sandor M, Chensue SW. CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection. The American journal of pathology. 2011;178(1):233-44. doi: 10.1016/j.ajpath.2010.11.036. PubMed PMID: 21224060; PubMed Central PMCID: PMC3069872.
Stolberg VR, Chiu BC, Martin BE, Shah SA, Sandor M, Chensue SW. Cysteine-cysteinyl chemokine receptor 6 mediates invariant natural killer T cell airway recruitment and innate stage resistance during mycobacterial infection. Journal of innate immunity. 2011;3(1):99-108. doi: 10.1159/000321156. PubMed PMID: 21042003; PubMed Central PMCID: PMC3245832.
Baiu DC, Sandor M, Hart M. CD4+ T cells sensitized by vascular smooth muscle induce vasculitis, and interferon gamma is critical for the initiation of vascular pathology. The American journal of pathology. 2010;177(6):3215-23. doi: 10.2353/ajpath.2010.090985. PubMed PMID: 20971729; PubMed Central PMCID: PMC2993301.
McElvania Tekippe E, Allen IC, Hulseberg PD, Sullivan JT, McCann JR, Sandor M, et al. Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PloS one. 2010;5(8):e12320. doi: 10.1371/journal.pone.0012320. PubMed PMID: 20808838; PubMed Central PMCID: PMC2924896.
Schreiber HA, Hulseberg PD, Lee J, Prechl J, Barta P, Szlavik N, et al. Dendritic cells in chronic mycobacterial granulomas restrict local anti-bacterial T cell response in a murine model. PloS one. 2010;5(7):e11453. doi: 10.1371/journal.pone.0011453. PubMed PMID: 20625513; PubMed Central PMCID: PMC2897891.
Lee J, Sandor M, Heninger E, Fabry Z. Mycobacteria-induced suppression of autoimmunity in the central nervous system. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2010;5(2):210-9. doi: 10.1007/s11481-010-9199-6. PubMed PMID: 20333556; PubMed Central PMCID: PMC2875250.
Schreiber HA, Prechl J, Jiang H, Zozulya A, Fabry Z, Denes F, et al. Using carbon magnetic nanoparticles to target, track, and manipulate dendritic cells. Journal of immunological methods. 2010;356(1-2):47-59. doi: 10.1016/j.jim.2010.02.009. PubMed PMID: 20219468; PubMed Central PMCID: PMC2937839.