Karl W. Broman, PhD

Portrait of Karl W. Broman, PhD
Biostatistics and Medical Informatics
6763 MSC
1300 University Ave
Madison, WI 53706
(608) 262-4633
Focus Groups: 
Signal Transduction
PhD, Statistics, University of California, Berkeley
Research Summary: 
Statistics and statistical genetics
Research Detail: 

I am interested in statistical problems in genetics, genomics, and molecular biology. I am particularly interested in the development of improved methods for detecting and identifying genes contributing to variation in complex traits in humans and experimental organisms.

Selected Publications: 
Manichaikul A, Moon JY, Sen S, Yandell BS, Broman KW (2009) A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics 181:10771086
Sen S, Johannes F, Broman KW (2009) Selective genotyping and phenotyping strategies in a complex trait context. Genetics 181:16131626
Venkatesan M, Broman KW, Sellers M, Rasgon JL. An initial linkage map of the West Nile Virus vector Culex tarsalis. Insect Mol Biol, to appear
Broman KW, Sen S. A Guide to QTL Mapping with R/qtl. Springer, New York, to appear Aug, 2009
Sinha D, Klise A, Sergeev Y, Hose S, Bhutto IA, Hackler L, Malpic-Ilanos T, Samtani S, Grebe R, Goldberg MF, Hejtmancik JF, Nath A, Zack DJ, Fariss RN, McLeod DS, Sundin O, Broman KW, Lutty GA, Zigler JS Jr (2008) βA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Mol Cell Neurosci 37:8595
Roy-Gagnon M-H, Mathias RA, Fallin MD, Jee SH, Broman KW, Wilson AF (2008) An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: The revised ROMP method. Ann Hum Genet 72:115125
Bjornsson HT, Albert TJ, Ladd-Acosta CM, Green RD, Rongione MA, Middle CM, Irizarry RA, Broman KW, Feinberg AP (2008) SNP-specific array-based allele-specific expression analysis. Genome Res 18:771779
Paigen K, Szatkiewicz JP, Sawyer K, Leahy N, Parvanov ED, Ng SH, Graber JH, Broman KW, Petkov PM (2008) The recombinational anatomy of a mouse chromosome. PLoS Genet 4(7): e1000119
Lupi I, Broman KW, Tzuo S-C, Gutenberg A, Martino E, Caturegli P (2008) Novel autoantigens in autoimmune hypophysitis. Clin Endocrinol 69:269278
Hill M, Broman KW, Stupka E, Smith W, Jiang D, Sidow A (2008) The C. savignyi genetic map and its integration with the reference sequence facilitates insights into chordate genome evolution. Genome Res 18:13691379