My research focuses on the host response to biofilm infections, with the goal of devising new approaches for diagnosis and treatment of these common infections. Patients with indwelling medical devices, such as venous catheters, are at risk for invasive disease caused by various fungal and bacterial pathogens. In these patients, organisms adhere to the device surface and proliferate as a biofilm of resilient cells encased in an extracellular matrix. As the host immune system and conventional anti-infectives are often not capable of eradicating biofilms, these infections can have devastating consequences. Our laboratory studies Candida, the most common nosocomial fungal pathogen, and how the transition to the biofilm lifestyle protects Candida from immune clearance.
Jeniel Nett, MD. PhD
Microbial Sciences Building
1550 Linden Dr
Madison, WI 53706
MD, University of Wisconsin-Madison
PhD, Cellular and Molecular Biology, University of Wisconsin-Madison
Molecular Mycology, Marine Biology Laboratory, Woods Hole MA
The host response to biofilm infections, with the goal of devising new approaches for diagnosis and treatment of these common infections.
Nett, JE, E Brooks, J Cabezas-Olcoz, H Sanchez, R Zarnowski, K Marchillo, and DR Andes. 2014. Rat indwelling urinary catheter model of Candida albicans biofilm infection. Infect Immun. PMID: 25183731
Zarnowski R, W Webster, G Ade Lacmbouh, J Marita, J Bothe, J Berhardt, A Lounes-Hadj Sahraoui, J Fontaine, H Sanchez, R Hatfield, J Ntambi, J Nett, A Mitchell, D Andes. 2014. Novel entries in a fungal biofilm matrix encyclopedia. MBio. 5(4). PMID:25096878
Nett, JE. 2014. Future directions for anti-biofilm therapeutics targeting Candida. Expert Rev. Anti Infect.Ther. PMID: 24506174. Policy exempt – Review.
Taff HT, JE Nett, R Zarnowski, KM Ross, H Sanchez, MT Cain, J Hamaker, AP Mitchell, DR Andes. 2012. A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance. PLoS Path. 8(8): PMID:22876186. PMCID: PMC3410897.
Tebbets B, D Stewart, S Lawry, J Nett, A Nantel, D Andes, BS Klein. 2012. Characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One. 7(5). PMID:22574132. PMCID: PMC3344848.
Nett JE, K Marchillo, DR Andes. 2012. Modeling of fungal biofilms using a rat central vein catheter. Methods Mol Biol. 845:547-56. PMID:22328403. PMCID: PMC3341608.
Finkel JS, W Xu, D Huang, EM Hill, JV Desai, CA Woolford, JE Nett, H Taff, CT Norice CT, DR Andes, F Lanni, AP Mitchell. 2012. Portrait of Candida albicans adherence regulators. PLoS Path. 8(2). PMID:22359502. PMCID: PMC3280983.