His research efforts focus on myeloma research and phase I experimental therapeutics. He will build on his previous work in the genetics of multiple myeloma, myeloma stem cells and the development of genetically engineered models for multiple myeloma. Fotis has previously contributed to the molecular mapping of 20q deletions (with Tony Green in Cambridge) and the epigenetics of clonal evolution of CML (with Dina Ben Yehuda in Jerusalem). With Harold Varmus he created a novel animal model for multiple myeloma. In addition Fotis is studying the genetic requirements for progression of myeloma and treatment response in the Vk*MYC myeloma model.
Fotis Asimakopoulos, MB, BChir, PhD
1111 Highland Ave
Madison, WI 53705
Bachelor of Medicine, Bachelor of Surgery, Doctor of Philosophy, (Cambridge combined MD/ PhD program), University of Cambridge, United Kingdom
Myeloma research and phase I experimental therapeutics
Asimakopoulos F. and Varmus HE. Gene targeting of germinal center centroblasts generated in vivo. Manuscript in preparation.
Asimakopoulos F. and Varmus HE. Cell-Specific Transduction Of Blimp-1-expressing Lineages Mediated By A Receptor For Avian Leukosis Virus Subgroup B. Journal of Virology, 83: 4835-4843, 2009.
Shteper PJ, Siegfried Z, Asimakopoulos F.A., Palumbo GA, Rachmilewitz EA, Ben-Neriah Y, Ben-Yehuda D. ABL1 methylation in Ph-positive ALL is exclusively associated with the P210 form of BCR-ABL. Leukemia, 15: 575-82, 2001.
Asimakopoulos F.A., Shteper PJ, Krichevsky S, Fibach E, Polliack A, Rachmilewitz E, Ben- Neriah Y, Ben-Yehuda D. ABL1 Methylation is a Distinct Molecular Event Associated With Clonal Evolution of Chronic Myeloid Leukemia. Blood, 94: 2452-60, 1999.
Bench A.J., Aldred M.A., Humphray S.J., Champion K.M., Gilbert J.G., Asimakopoulos FA, Deloukas P., Gwilliam R., Bentley D.R., and Green A.R. A Detailed Physical And Transcriptional Map Of The Region Of Chromosome 20 That Is Deleted In Myeloproliferative Disorders And Refinement Of The Common Deleted Region. Genomics, 49: 351-362, 1998.
Champion K.M., Gilbert J.G.R, Asimakopoulos F.A., Hinshelwood S. and Green A.R. Clonal Haematopoiesis In Normal Elderly Women: Implications For The Myeloproliferative Disorders And Myelodysplastic Syndromes. British Journal of Haematology, 97: 920-926, 1997.
Asimakopoulos FA, Hinshelwood S., Gilbert J.G.R., Delibrias C.C., Göttgens B., Fearon D.T., and Green A. R. The Gene For Hematopoietic Cell Phosphatase (SHP-1) Is Structurally And Transcriptionally Intact In Polycythemia Vera. Oncogene, 14: 1215-1222, 1997.
Asimakopoulos F.A., White N.J., Nacheva E. and Green A.R. The Human CD40 Gene Maps Within Chromosome 20q Deletions Associated With Myeloid Malignancies. British Journal of Haematology, 92: 127-130, 1996.
Asimakopoulos F.A., Holloway T.L., Nacheva E., Scott M.A., Fenaux P. and Green A.R. Detection Of Chromosome 20q Deletions In Bone Marrow Metaphases But Not Peripheral Blood Granulocytes In Patients With Myeloproliferative Disorders Or Myelodysplastic Syndromes. Blood, 87: 1561-1570, 1996.
Asimakopoulos F.A., Gilbert J.G.R., Aldred M.A., Pearson T.C., and Green A.R. Interstitial Deletion Constitutes The Major Mechanism For Loss Of Heterozygosity On Chromosome 20q In Polycythaemia Vera. Blood, 88: 2690-2698, 1996. Gilbert J.G.R., Aldred M.A., Pearson T.C., and Green A.R. Interstitial Deletion Constitutes The Major Mechanism For Loss Of Heterozygosity On Chromosome 20q In Polycythaemia Vera. Blood, 88: 2690-2698, 1996.