Signal Transduction Trainers

The graduate faculty and a brief statement of their research interests are listed below. Many of these individual research programs are funded by awards from a variety of funding resources. Inquiries regarding space in a laboratory and availability of research support should be directed to the individual faculty member.

Portrait of Caroline Alexander, PhD
Oncology
Research Summary: Mammary stem cells; Mouse mammary tumor models; Wnt signaling; Syndecan-1
Portrait of B. Lynn Allen-Hoffmann, PhD
Pathology and Laboratory Medicine
Research Summary: Keratinocytes; cancer biology; extracellular matrices
Biochemistry
Research Summary: Molecular genetics of type 2 diabetes
Portrait of Craig S. Atwood, PhD
Medicine
Research Summary: Aging; endocrinology; development; degenerative diseases of the central nervous system
Portrait of Emery Bresnick, PhD
Cell and Regenerative Biology
Research Summary: Stem Cell Biology, Epigenetics, Molecular Hematology, Vascular Biology, Cancer Biology: From Fundamental Mechanisms to Translational Medicine
Portrait of Karl W. Broman, PhD
Biostatistics and Medical Informatics
Research Summary: Statistics and statistical genetics
Portrait of Wade Bushman, MD, PhD
Urology
Research Summary: Hedgehog signaling in prostate development and prostate cancer; role of inflammatory signaling in regenerative-repair, hyperplasia and neoplasia; Role of prostate inflammation in producing prostate obstruction and changes in bladder function
Portrait of Joshua Coon, PhD
Chemistry
Research Summary: Bioanalytical Chemistry, Chemical Biology, Systems Biology, Mass Spectrometry, Proteomics
Portrait of Arjang Djamali, MD
Medicine
Research Summary: The cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease
Portrait of Feyza Engin, PhD
Biomolecular Chemistry
Research Summary: Type 1 diabetes (T1D) results from the destruction of the insulin-secreting b-cells by an immune mediated process. The increasing incidence of type 1 diabetes around the word, especially among children, has been of great concern.
Portrait of Andreas Friedl, MD
Pathology and Laboratory Medicine
Research Summary: Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Ophthalmology and Visual Sciences
Portrait of Ying Ge, PhD
Cell and Regenerative Biology
Research Summary: Cardiovascular Systems Biology through High-resolution Mass Spectrometry-based Comparative Proteomics and Metabolomics
Portrait of Daniel S. Greenspan, PhD
Cell and Regenerative Biology
Research Summary: Extracellular modulators of cellular behaviors in development, homeostasis, and disease
Portrait of Lian-Wang Guo, MS, PhD
Surgery
Research Summary: Mechanisms of restenosis, proliferation and inflammation, retinal neurodegeneration and regeneration, neural progenitor/stem cells.
Portrait of Michelle E. Kimple, PhD
Medicine
Research Summary: Guanine Nucleotide Binding Proteins, pancreatic beta-cell biology, insulin secretion, diabetes pathophysiology
Portrait of Dudley Lamming, PhD
Medicine
Research Summary: The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
Portrait of Youngsook Lee, PhD
Cell and Regenerative Biology
Research Summary: Transcriptional control of normal cardiovascular development and function
Portrait of Bo Liu, PhD
Surgery
Research Summary: Vascular diseases, cell apoptosis, inflammation, signaling, adult progenitor cells, gene therapy
Portrait of Deane Mosher, MD
Biomolecular Chemistry
Research Summary: Extracellular matrix; cell adhesion
Portrait of Donna Peters, PhD
Pathology and Laboratory Medicine
Research Summary: Cell-matrix signaling in the human eye; glaucoma
Portrait of Alan C. Rapraeger, PhD
Human Oncology
Research Summary: Cell surface proteoglycans, heparin-binding growth factors
Medicine
Research Summary: Molecular regulation of the coagulation serine proteases; novel therapeutic targets for antithrombotic therapy; mechanisms for hormone-induced and cancer-associated thrombosis.
Portrait of Nader Sheibani, PhD
Ophthalmology and Visual Sciences
Research Summary: The role of cell-cell and cell-matrix interactions in vascular development and neovascularization
Portrait of Rupa Sridharan, PhD
Cell and Regenerative Biology
Research Summary: Stem Cell Biology, Epigenetics of cell fate change, Induced Pluripotent Stem cells.
Portrait of John Svaren, PhD
Comparative Biosciences
Research Summary: Role of EGR and NAB proteins in peripheral nerve myelination; genomic analysis of physiological regulation; role of chromatin structure in gene regulation
Comparative Biosciences
Research Summary: • Regulation of microglial gene transcription • Microglial signal transduction mechanisms in paradigms of hypoxia • Epigenetic modulation of microglial phenotypes • Sex differences in microglial responses in chronic neuroinflammatory disease
Portrait of Weixiong Zhong, MD, PhD
Pathology and Laboratory Medicine
Research Summary: Oxidative stress and redox regulation in carcinogenesis and cancer chemoprevention