Dudley Lamming, PhD

Portrait of Dudley Lamming, PhD
Assistant Professor
Medicine
Address: 
2500 Overlook Terr
VAH C3127 Res 151
Madison, WI 53705
Telephone: 
(608) 256-1901 x12861
Focus Groups: 
Cancer Biology
Signal Transduction
Education: 
PhD, Harvard University
BS, Massachusetts Institute of Technology
Research Summary: 
The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
Research Detail: 

The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer's disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

Selected Publications: 
Fontana L*#, Cummings NE*, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME,Lamming DW#. Decreased consumption of branched chain amino acids improves glycemic control. Cell Reports, in press.
Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW#, Merrins MJ#. Pancreatic β cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity. Diabetes, 2016 Jun 9. pii: db160432. [Epub ahead of print] Pubmed PMID: 27284112 PubMed Central PMCID: In progress.
Arriola Apelo SI, Lamming DW. Rapamycin: An InhibiTOR of Aging Emerges From The Soil of Easter Island. J Geron Biol Sci, 2016, May 21. pii: glw090. [Epub ahead of print]. Pubmed PMID: 27208895; PubMed Central PMCID: In progress.
Arriola Apelo SI, Pumper CP, Baar EL, Cummings NE, Lamming DW. Intermittent administration of rapamycin extends the lifespan of female C57BL/6J mice. J Geron Biol Sci, 2016, Apr 18. pii: glw064. [Epub ahead of print]. PMID: 27091134 PMCID: In progress.
Baar EL, Carbajal KA, Ong IO, Lamming DW. Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice. Aging Cell.2016; 15(1):155-66. doi: 10.1111/acel.12425. Epub 2015 Nov 24. PMID: 26695882; PubMed Central PMCID: PMC4717274.
Lamming DW#, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L#. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget. 2015; 6(31):31233-40. doi: 10.18632/oncotarget.5180. Pubmed PMID: 26378060; PubMed Central PMCID: PMC4741600
Lamming DW*, Ye L*, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335(6076):1638-43. Epub 2012/03/31. doi: 10.1126/science.1215135. PubMed PMID: 22461615; PubMed Central PMCID: PMC3324089.
Lamming DW#, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana F#. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget 2015, in press.
Lamming DW#, Mihayalova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM#. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell 2014: doi: 10.1111/acel.12256; PubMed PMID: 25059582; PubMed Central PMCID: PMC4172536.
Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 2014; 28(1):300-15. doi: 10.1096/fj.13-237743. PubMed PMID: 24072782; PubMed Central PMCID: PMC3868844.
Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Lamming DW, Ye L, Sabatini DM, Baur JA. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest. 2013; 123(3):980-9. Epub 2013/03/05. doi: 10.1172/JCI64099. PubMed PMID: 23454761; PubMed Central PMCID: PMC3582126.
Lamming DW*, Ye L*, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335(6076):1638-43. Epub 2012/03/31. doi: 10.1126/science.1215135. PubMed PMID: 22461615; PubMed Central PMCID: PMC3324089.