Dr. Pepperell's research focuses on the ecology and evolution of human pathogens. Infectious diseases differ from other human diseases in that they involve the interplay between distinct species with mostly antagonistic goals. Many of the techniques developed in the field of evolutionary biology are well suited to the study of these dynamic systems and are promising tools in the search for improved methods to control and treat infectious diseases.
Caitlin S. Pepperell, MD
1500 Linden Drive
Madison, WI 53706-1521
MD, Queen’s of Toronto, Ontario, Canada
Xiong, Donny, Jennifer K. Meece, Corinne D. Engelman, and Caitlin S. Pepperell. Genetic Research with Hmong-ancestry Populations: Lessons from the Literature and a Pilot Study. Hmong Studies Journal, 14(2013): 1-28
Pepperell CS, Casto AM, Kitchen A, Granka JM, Cornejo OE, Holmes EC, Birren B, Galagan J, Feldman MW. The Role of Selection in Shaping Diversity of Natural M.tuberculosis Populations. PLoS Pathogens, 2013 Aug; 9(8): e1003543.
Pepperell CS, Chang AH, Wobeser W, Parsonnet J, Hoeppner VH. Local epidemic history as a predictor of tuberculosis incidence in Saskatchewan Aboriginal communities. Int J Tuberc Lung Dis. 2011 Jul;15(7):899-905.
Pepperell CS, Granka JM, Alexander DC, Behr MA, Chui L, Gordon J, Guthrie JL, Jamieson FB, Langlois-Klassen D, Long R, Nguyen D, Wobeser W, Feldman MW. Dispersal of Mycobacterium tuberculosis via the Canadian fur trade. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6526-31. Epub 2011 Apr 4.
Pepperell C, Hoeppner VH, Lipatov M, Wobeser W, Schoolnik G, Feldman MW. Bacterial genetic signatures of human social phenomena among M. tuberculosis from an Aboriginal Canadian population. Mol Biol Evol 2010 Feb; 27(2): 427-40.
Burton JM, Kern RZ, Halliday W, Mikulis D, Brunton J, Fearon M, Pepperell C, Jaigobin C. Neurological manifestations of West Nile virus infection. Can J Neurol Sci 2004;31(2):185-93.
Pepperell C, Rau N, Krajden S, Kern R, Humar A, Mederski B, Simor A, Low DE, McGeer A, Mazzulli T, Burton J, Jaigobin C, Fearon M, Artsob H, Drebot MA, Halliday W, Brunton J. West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. CMAJ. 2003 May 27;168(11):1399-405.
Pepperell C, Kus JV, Gardam MA, Humar A, Burrows LL. Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60.