Bo Liu, PhD

Portrait of Bo Liu, PhD
Associate Professor
Surgery
Address: 
5137 WIMR
1111 Highland Ave
Madison, WI 53705
Telephone: 
(608) 263-5931
Focus Groups: 
Signal Transduction
Education: 
PhD, Biochemistry, SUNY Downstate
Research Summary: 
Vascular diseases, cell apoptosis, inflammation, signaling, adult progenitor cells, gene therapy
Research Detail: 

A major research goal of Liu’s lab is to understand the pathophysiology of vascular disease including atherosclerosis, restenosis (intimal hyperplasia) and abdominal aortic aneurysms. Using a combination of molecular, biochemical and genetic approaches, Dr. Liu and her co-investigators identified several intracellular signaling proteins that are critical in regulation of vascular smooth muscle cells, endothelial cells, fibroblasts and progenitor cells. Current research topics include interaction between smooth muscle cell apoptosis and vascular inflammation, progenitor cell recruitment and differentiation, signaling pathways underlying apoptosis, migration, cytokine expression and other functions of smooth muscle cells. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, who has created a lab environment that fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Selected Publications: 
Kato K, Yamanochi D, Kamiya K, Zhang F, Kent KC, and Liu B. Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2009 297:H2253-61
Yamanouchi D, Kato K, Ryer RJ, Zhang F, and Liu B. Protein kinase C-delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis. Cardiovascular Res 2010 85:434-43
Yamanouchi D, Kato K, Morgan S, Lengfeld J, Zhang F, and Liu B. Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2010 30:702-707
Saurer EM, Yamanouchi D, Liu B, Lynn DM. Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers. Biomaterials. 2011 32:618-8
Lengfeld J, Wang Q, Zohlman A, Salvarezza S, Morgan S, Ren J, Kato K, Rodriguez-Boulan E, and Liu B Protein Kinase C Delta Regulates the Release of Collagen Type I from Vascular Smooth Muscle Cells via regulation of Cdc42. Mol Bio Cell (in press)
Suwanabol PA, Zhang F, Seedial S, Shi X, Yi S, Liu B and Kent KC TGF- and Smad3 modulate PI3K/Akt signaling pathways in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2012 302:H2211 (PMC3408812)
Yamanouchi D, Morgan S, Stair C, Seedial S, Lengfeld J, Kent KC, and Liu B. Accelerated aneurysmal dilatation associated with apoptosis and inflammation in a newly created modified calcium chloride rodent AAA model. J Vasc Surg 2012 56:455. (PMC3408782)
Si Y, Ren J, Wang P, Rateri D, Daugherty A, Shi X, Kent KC, and Liu B. Protein kinase C-delta mediates adventitial cell migration through regulation of monocyte chemoattractant protein-1 expression in a rat angioplasty model. Arterioscler Thromb Vasc Biol. 2012 32:943-54 (PMC3311123)
Morgan S, Yamanouchi D, Harberg C, Keller, M, Burlingham W, Seedial S, Lengfeld J, and Liu B. Protein Kinase C-delta regulates inflammation in mouse abdominal aortic an eurysm through monocyte chemoattractant Protein-1. Arterioscler Thromb Vasc Biol. 2012 32:2493 (PMC3442600)
Goel SA, Guo LW, Shi XD, Kundi R, Sovinski G, Seedial S, Liu B, Kent KC. Preferential secretion of collagen type 3 versus type 1 from adventitial fibroblasts stimulated by TGF-β/Smad3-treated medial smooth muscle cells. Cell Signal. 2013 25:955-60. (PMC3595331)
Shi X, Chen G, Guo LW, Si Y, Xhu M, Pilla S, Liu B, Gong S, Kent KC Periadventitial application of rapamycine-loaded nanoparticles produces sustained inhibition of vascular restenosis. PloS One 2014 9: e89227 (PMC3931710)
Wang Q, Ren J, Morgan S, Liu Z, Dou C, and Liu B. Monocyte Chemoattractant Protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. PloS One 2014 9:e92053 (PMC3954911)
Ren J, Wang Q, Morgan S, Si Y, Ravichander A, Dou C, Kent KC, and Liu B Protein Kinase C-delta regulates pro-inflammatory chemokine expression through cytosolic interaction with the NFκB subunit p65 in vascular smooth muscle cells. J Biol Chem 2014 289:9013 (PMC3979373)
Liu Z, Wang Q, Ren J, Assa CR, Morgan S, Giles J, Han Q, and Liu A murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta. J Vas Surg 2014 (in press)