My research interests are centered on understanding what factors lead to successful cognitive aging, and what risk factors are associated with pathological brain aging. My recent work is focused on understanding the effect of factors that contribute to or protect against the development of Alzheimer’s disease (AD). Together with collaborators across campus, my studies enroll people in middle and late age who may be at increased risk for developing AD due to parental family history, genotype, or vascular risk factors. My projects use magnetic resonance imaging (MRI) as a tool to understand the effect of risk on brain blood flow and structure. Additionally, I am funded to examine the relationship between cerebrospinal fluid biomarkers and brain structure to learn more about early mechanisms of brain damage in AD. Learning more about the earliest brain changes involved in AD is expected to lead to earlier diagnosis, prevention, and the development of new therapies for AD.
Barbara Bendlin, PhD
J5/1 Mezzanine CSC
600 Highland Avenue
Madison, WI 53792
Aging; Alzheimer's disease, Neurobiology of Disease, Behavior and Cognition
Bendlin BB, Canu E, Willette AA, Kastman EK, McLaren DG, Kosmatka KJ, Xu G, Field AS, Colman RJ, Coe CL, Weindruch R, Alexander AL, Johnson, SC (2010). The effect of aging and calorie restriction on white matter in old rhesus macaques. Neurobiology of Aging (in press).
Johnson SC, La Rue A, Herman B, Xu G, Koscik R, Jonaitas E, Bendlin BB, Roses A, Saunders S, Lutz M, Asthana S, Green RC, Sager MA. The Effect of TOMM40 Poly-T length on Gray Matter Volume and Cognition in Middle-Aged Persons with APOE 3/3 Genotype. Alzheimer’s and Dementia (in press).
Willette AA, Gallagher C, Bendlin BB, McLaren DG, Kastman EK, Canu, E, Kosmatka, KJ, Field, AS, Alexander, AL, Colman, RJ, Voytko, ML, Weindruch, RH, Coe, CL, Johnson, SC. Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys. Neurobiology of Aging (in press).
Gallagher CL, Oakes TR, Johnson SC, Chung MK, Holden JE, Bendlin BB, Xu G, McLaren D, Nickles RJ, Pyzalski R, Dejesus O, Brown WD. Rate of 6-[18F]fluoro-L-dopa uptake decline in striatal subregions in Parkinson’s disease, Movement Disorders, in press.
Ryan L, Walther K, Bendlin BB, Lue LF, Walker DG, Glisky EL. Age-related differences in white matter integrity and cognitive function are related to APOE status. NeuroImage (in press).
Gallagher CL, Johnson SC, Bendlin BB, Chung MK, Holden JE, Oakes TR, Brooks BR, Konapacki RA, Dogan S, Abbs J, Xu G, Nickles RJ, Pyzalski RW, DeJesus OT, Brown WD. A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease, Brain Imaging and Behavior, in press.
Gallagher, CL, Christian BT, Holden JE, Dejesus OT, Nickles RJ, Buyan-Dent L, Bendlin BB, Harding SJ, Stone CK, Mueller B, Johnson SC. A within-subject comparison of 6-[18F]Fluoro-m-tyrosine and 6-[18F]Fluoro-L-dopa in Parkinson’s disease, Movement Disorders, in press.
McLaren DG, Kosmatka KJ, Kastman EK, Bendlin BB, Johnson SC (2010). Rhesus Macaque Brain Morphometry: A Methodological Comparison of Voxel-Wise Approaches. Methods, 50(3):157-65.
Canu E, McLaren DG, Fitzgerald ME, Bendlin BB, Zoccatelli G, Alessandrini F, Pizzini FB, Ricciardi GK, Beltramello A, Johnson SC, Frisoni GB (2010). Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer’s disease. Journal of Alzheimer's Disease, 19(3):963-76.
Bendlin BB, Carlsson CM, Gleason CE, Johnson SC, Sodhi A, Gallagher CL, Puglielli L, Engelmann CD, Ries ML, Xu G, Wharton W. Asthana S. (2010). Midlife Predictors of Alzheimer’s Disease. Maturitas, 65(2):131-7.