We are interested in examining the cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease. To this end, we use in vitro, animal and human studies. We are currently investigating the role of Nox and heat shock protein 27 in the pathogenesis of kidney injury. Study models are rat proximal tubular epithelial cells (NRK52E cell line) and murine models of kidney transplantation, unilateral ureteral obstruction and 5/6th nephrectomy. Ongoing translational studies are examining these processes in patients with chronic kidney disease and chronic allograft nephropathy.
Arjang Djamali, MD
1685 Highland Ave
Madison, WI 53792
MD, Montpellier Medical School, Montpellier, France
The cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease
Djamali A. Vidyasagar A, Adulla M, Hullett D, Reese S. Nox-2 is a modulator of fibrogenesis in kidney allografts. American Journal of Transplantation Jan 2009; 9(1):74-82.
Pascual J, Pirsch JD, Odorico JS, Torrealba JR, Djamali A, Becker YT, Voss B, Leverson GE, Knechtle SJ, Sollinger HW, Samaniego-Picota MD. Alemtuzumab Induction and Antibody-Mediated Kidney Rejection After Simultaneous Pancreas-Kidney Transplantation. Transplantation. 2009 Jan 15;87(1):125-132.
Bedi S, Vidyasagar A, Djamali A. Epithelial-to-Mesenchymal Transition and chronic allograft tubulointerstitial fibrosis. Transplantation Reviews 2008, 22 (1), 1-5.
Djamali A. Can the renal transplant patient be really considered as patient with chronic renal insufficiency? Nphrologie & Thrapeutique 4 (2008) S28-S31.
Rao AK, Djamali A, Korcarz CE, Aeschlimann SE, Wolff MR, Stein JH. Mitral Annular Calcification is Associated with Left Ventricular Dysfunction and Inflammation in Patients with Chronic Kidney Disease. American Heart Journal. J Am Soc Echocardiogr. 2008 Jan 8.
Kukla A, Adulla M, Pascual J, Samaniego M, Nanovic L, Becker B, Djamali A. Stage to Stage disease progression in native and transplant kidney disease. Nephrol Dial Transplant. 2008 Feb;23(2):693-700.
Pascual J, Samaniego MD, Torrealba JR, Odorico JS, Djamali A, Becker YT, Voss B, Leverson GE, Knechtle SJ, Sollinger HW, Pirsch JD. Antibody-Mediated Rejection of the Kidney after Simultaneous Pancreas-Kidney Transplantation. J Am Soc Nephrol. 2008 Jan 30
Rao AK, Djamali A, Korcarz CE, Aeschlimann SE, Wolff MR, Stein JH. Left atrial volume is associated with inflammation and atherosclerosis in patients with kidney disease. Echocardiography. 2008 Mar;25(3):264-9.
Conley E, Muth B, Samaniego M, Lotfi M, Voss B, Armbrust M, Pirsch J, Djamali A. Bisphosphonates and bone fractures in long-term kidney transplant recipients. Transplantation, 2008 Jul 27;86(2):231-7
Vidyasagar A, Reese S, Acun Z, Hullett D, Djamali A. HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F707-16.