Andreas Friedl, MD

Portrait of Andreas Friedl, MD
Department Chair
Pathology and Laboratory Medicine
6051 WIMR
1111 Highland Ave
Madison, WI 53705
(608) 265-9283
Focus Groups: 
Cancer Biology
Signal Transduction
Dr. of Medicine (Dr. med.), University of Erlangen, Germany
MD, University of Erlangen, Germany
Research Summary: 
Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Research Detail: 

My research focuses on the role of heparan sulfate proteoglycans (HSPGs) in tumorigenesis and cancer progression. HSPGs are hybrid molecules, which consist of core proteins and heparin-like polysaccharide domains. HSPGs are found in abundance on cell surfaces and in the extracellular matrix. One project focuses on the role of the HSPG syndecan-1 in stromal fibroblasts of breast carcinomas. The goal is to decipher the mechanisms by which stromal syndecan-1 stimulates breast carcinoma growth and invasion. A separate project aims at identifying the mechanisms by which the HSPG glypican-1 regulates cell cycle progression in brain tumor cells.

Selected Publications: 
Yang X, Friedl A. A positive feedback loop between prolactin and STAT5 promotes angiogenesis. Adv Exp Med Biol 846:265-80, 2015. PMID:25472543.
Yang and Friedl. Syndecan-1-induced ECM fiber alignment requires integrin αvβ3 and syndecan-1 ectodomain and heparan sulfate chains. PLoS ONE 11(2): e0150132, 2016. doi: 10.1371/journal.pone.0150132, 2016. PMCID: PMC4766302.
Qiao D, Yang X, Meyer K, and Friedl A. Glypican-1 Regulates Anaphase Promoting Complex/Cyclosome (APC/C) Substrates and Cell Cycle Progression in Endothelial Cells. Mol Biol Cell. 2008, 19:2789-80. PMCID: PMC2441674.
Su G, Blaine SA, Qiao D, Friedl A. Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res. 2008, 68:9558-65. PMCID: PMC2877371.
Yang X, Qiao D, Meyer K and Friedl A. Signal Transducers and Activators of Transcription (STATs) Mediate Specific Angiogenic Fibroblast Growth Factor Signaling Pathways. Cancer Res. 2009; 69(4):1668-77. PMCID: PMC2650265.
Friedl, A. Proteoglycans: Master Modulators of Paracrine Fibroblast - Carcinoma Cell Interactions. Semin Cell Dev Biol. 2010 Feb;21(1):66-71. PMCID: PMC2824000.
Bauer M, Su G, Casper C, He R, Rehrauer W and Friedl A. Heterogeneity of Gene Expression in Stromal Fibroblasts of Human Breast Carcinomas and Normal Breast. Oncogene 2010, 29(12):1732-40. PMCID: PMC2845730.
Yang N, Mosher R, Seo S, Beebe DJ and Friedl A. Syndecan-1 in Breast Cancer Stroma Fibroblasts Regulates Extracellular Matrix Fiber Organization and Carcinoma Cell Motility, Am J Pathol, 2011 Jan;178:325-35. PMCID: PMC3069862.
Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, and Keely PJ. Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol. 2011 Mar;178(3):1221-32. PMCID: PMC3070581.
Yang X, Qiao D, Meyer K, Pier T, Keles S and Friedl A. Signal Transducer and Activator of Transcriptor 5A (STAT5A)-Induced Angiogenesis is Dependent on Autocrine Proliferin (PLF-1) Activity. J Biol Chem. 2012 Feb 24;287(9):6490-502. PMCID: PMC3307309.
Su G, Sung K, Beebe DJ and Friedl A. Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts. PLOS ONE 7(10):1-12 (e46685), 2012. PMCID: PMC3466317.
Yang X, Meyer K, and Friedl A. STAT5 and Prolactin Participate in a Positive Autocrine Feedback Loop that Promotes Angiogenesis. J Biol Chem 2013 (in press).
Sung K, Su X, Berthier E, Pehlke C, Friedl A, Beebe DJ. Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. PLOS ONE Oct;8(10):e76373, 2013. doi:10.1371/journal.pone.0076373. PMCID: PMC3790689.