Lisa M. Arendt, DVM, PhD

Portrait of Lisa M. Arendt, DVM, PhD
Assistant Professor
Comparative Biosciences
Address: 
School of Veterinary Medicine
2015 Linden Dr. Rm 4354A
Madison, WI 53706
Telephone: 
(608) 890-2265
Focus Groups: 
Cancer Biology
Immunology/Immunopathology
Education: 
PhD, University of WI-Madison
DVM, University of WI-Madison
Research Summary: 
Breast cancer, tumor/stromal interactions, cancer stem cells, mammary stem cells, Human-in-Mouse Model, inflammation and tumor microenvironment, adipose stem cells
Research Detail: 

Obesity is becoming a global epidemic and is one of the important risk factors associated with breast cancer in postmenopausal women.  However, regardless of menopausal status, obese women that are diagnosed with breast cancer develop larger, more aggressive tumors, with an increased incidence of metastases. Since breast tissue is a reservoir of subcutaneous adipose tissue, elucidating the changes in adipose tissue under conditions of obesity is critical for prevention and treatment of obesity-associated cancer. 

In order to understand how obesity alters the microenvironment of the breast, we utilize high fat diet and transgenic mouse models of obesity, a novel human xenograft model to observe tumor development, and complementary in vitro cell culture models.  Our lab has three main focus areas: understanding how adipokines secreted by obese adipocytes act in the microenvironment of the breast, elucidating the role of inflammation induced by obesity in breast tumor progression and metastasis, and investigating how obesity alters breast epithelial cell populations leading to changes in breast cancer risk.

Selected Publications: 
Arendt LM and Kuperwasser C. Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy. Journal of Mammary Gland Biology and Neoplasia, 2015; in press.
Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto A, Georgakoudi I. Rapid three-dimensional quantification of voxel-wise collagen fiber orientation. Biomedical Optics Express 2015; 6: 2294-2310.
Wronski A, Arendt LM, Kuperwasser C. Humanization of the mouse mammary gland. Methods in Molecular Biology 2015; 1293:173-186.
Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Kuperwasser C, Walt DR. Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring. Scientific Reports, 2015; 5:11034.
Mazumdar S*, Arendt LM*, Philips S, Sedic M, Kuperwasser C, Gill G. CoREST1 promotes tumor formation and tumor stroma interactions. PlosOne 2015; 10 (3):e0121281. *These authors contributed equally to this work.
Arendt LM, St. Laurent J, Keller PJ, Callebero S, Lyle S, Naber SP, et al. Hormonal and non-hormonal regulation of distinct lineage-committed progenitor cells in the human breast requires WNT and TBX3. PlosOne 2014; 9: e111442.
Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Kuperwasser C. Immature lobules of the human breast are enriched for progenitor cells. Breast Cancer Research 2014; 16:453.
McCready J, Arendt LM, Glover E, Iyer V, Lyle S, Naber SP, Jay DG, Kuperwasser C. Adipose stromal cells present during lactation promote angiogenesis and breast tumor growth. Breast Cancer Research 2014; 16(1): R2.
Arendt LM, McCready J, Keller PJ, Naber SP, Baker DB, Seewaldt V, Kuperwasser C. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Research 2013; 73(19): 1-14.
Iyer V, Klebba I, McCready J, Arendt LM, Betacur-Boissel M, Wu MF, Zhang X, Lewis MT, Kuperwasser C. Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone-marrow derived monocytes. Cancer Research 2012; 72(11): 2705-2713.