Angela Gibson, MD, PhD

Angela Gibson, MD, PhD
Assistant Professor
MD University of Wisconsin Madison School of Medicine and Public Health
PhD University of Wisconsin Graduate School
Research Summary: 
·Burn wound healing ·Autologous epithelial regeneration and mesenchymal stem cell contribution ·Ex-vivo wound healing models ·Translational wound healing research
Research Detail: 

Each year, nearly 11 million people worldwide sustain burn injuries severe enough to require medical attention. These injuries are often associated with significant life-long morbidity, including pain, scarring, and infection. The Gibson lab is interested in studying the basic cellular and micro-environmental requirements necessary for burn wound healing in humans. The minimum dermal elements remaining after burn injury that are required for autologous regeneration of the wound is unknown.

Mouse animal models have been used extensively to characterize wound healing; however, there are concerns about extrapolating the findings given the fundamental differences in skin anatomy and wound healing between rodent models and humans. To avoid using a mouse model and given the access our lab has to human tissue, we are using discarded human skin as an ex-vivo burn model. Additionally, we utilize human burn tissue from UW burn patients through a biobank the Gibson lab has developed. In the near future, we will be developing a porcine burn model as an in vivo burn model to facilitate translation of our research.

We are interested in the contributions of the seed versus the soil (cellular vs extracellular matrix) to wound healing and clinical translation of these findings to improve wound healing in burn patients. We use a variety of techniques including tissue culture, basic histology, immunohistochemistry and molecular biology methods to answer our questions. We are collaborating with an imaging expert (Dr. Eliceiri) at LOCI to utilize advanced imaging methods to understand burn wound healing. We are also collaborating with a collagen chemistry expert (Dr. Raines) to utilize a novel collagen mimetic peptide for diagnostic and therapeutic use in burn injury. Furthermore, Dr. Gibson is the site PI on two multi-center clinical trials of human skin substitutes (StrataGraft®) on burn patients at the UW Health Burn Center.

Selected Publications: 
Gibson, A and Shatadal, S. “A Simple and Improved Method to Determine Cell Viability in Burn Injured Tissue”. Journal of Surgical Research. Accepted March 2017.
Israel, J., Greenhalgh, D., Gibson, A. “Variations in Burn Excision and Grafting: A Survey of the American Burn Association” Journal of Burn Care and Research. 2017 Jan/Feb 38(1)e125-e132.
Gibson, A., Thomas-Virnig, C., Centanni, J., Schlosser, S., Johnston. C., Van Winkle, K., Szilagyi, A.,He, L., Shankar, R., Allen-Hoffmann, B.L., “Non-viral human beta defensin-3 expression in a bioengineered human skin tissue: a therapeutic alternative for infected wounds.” Wound Repair and Regeneration. 2012 May-Jun;20:414–524.
Gibson, A., Faucher, L., Schurr, M. “Molten Copper Inhalation.” BURNS. 2011 Sept; 37(6)e50-53.
Rasmussen C., Gibson A., Schlosser S., Schurr M., Allen-Hoffmann B.L. “Chimeric Composite Skin Substitutes for Delivery of Autologous Keratinocytes to Promote Tissue Regeneration.” Annals of Surgery. 2010 Feb;251(2)368-376
Straseski J., Gibson A., Thomas-Virnig C., Allen-Hoffmann B.L. “Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen.” Wound Repair and Regeneration. 2009 Jul-Aug;17(4):606-616.
Schurr M., Foster K., Centanni J., Comer A., Wicks A, Gibson A., Thomas-Virnig C., Schlosser S., Faucher L., Lokuta M., Allen-Hoffmann B.L. "Phase I/II clinical evaluation of StrataGraft: a consistent, pathogen-free human skin substitute." Journal of Trauma. 2009 Mar; 66(3):866-873; discussion 873-874.
Thomas-Virnig C., Centanni J., Johnston C., He L., Schlosser S., Van Winkle K., Chen R., Gibson A., Szilagyi A., Li L, Shankar R., Allen-Hoffmann B.L. “Inhibition of multidrug-resistant Acinetobacter baumannii by nonviral expression of hCAP-18 in a bioengineered human skin tissue.” Molecular Therapy. 2009 Mar;17(3):562-569. Epub 2009 Feb 3.
Gibson A., Schurr M., Schlosser S., Comer A., Allen-Hoffmann B.L. "Comparison of therapeutic antibiotic treatments on tissue-engineered human skin substitutes." Tissue Engineering Part A. 2008 May;14(5):629-638.