Feyza Engin, PhD

Portrait of Feyza Engin, PhD
Assistant Professor
Biomolecular Chemistry
6260B Biochemical Sciences Building
440 Henry Mall
Madison, WI 53706
(608) 262-8667
Focus Groups: 
Signal Transduction
PhD, Baylor College of Medicine
Research Summary: 
Type 1 diabetes (T1D) results from the destruction of the insulin-secreting b-cells by an immune mediated process. The increasing incidence of type 1 diabetes around the word, especially among children, has been of great concern.
Selected Publications: 
Engin, F., Yermalovich, A., Ngyuen, T., Hummasti, S., Fu, W., Eizirik, DL., Mathis, D., Hotamisligil, GS. “ATF6-dependent restoration of defective beta cell UPR with TUDCA protects mice against type 1 diabetes Sci Transl Med (in press).
Engin, F., Hotamisligil, GS. “Chemical modulation of ER function in metabolic diseases”. Diabetes Obes Metab. 2010. 12 Suppl 2:108-15. PMID: 21029307.
Yang, T., Londono, R.M., Lu, H., Li, K., Keller, B., Jiang, M.M., Chen, Y., Bertin, T., Engin, F., Dabovic, B., Rifkin, D.B., Hicks, J, Beaudet, A.L., Lee, B. “E-Selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-”. J Clin Invest. 2010. 1; 120(7): 2474-85. PMCID: 2898604.
Engin, F., Lee B. “NOTCHing the bone: insights into multi-functionality”. Bone. 2010; 46(2): 274-280. PMID: 19520195. PMCID: 2835535.
Engin, F., Bertin, T., Ma, O., Jiang, MM., Wang, L., Sutton, RE., Donehower, LA., Lee, B. “Notch signaling contributes to the pathogenesis of human osteosarcomas”. Hum Mol Genet. 2009; 18(8): 1464-1470. PMID: 19228774. PMCID: 2733809.
Engin, F., Yao, Z., Yang, T., Zhou, G., Bertin, T., Jiang, M.M., Chen, Y., Wang, L., Zheng, L., Sutton, R.E., Boyce, B.F., Lee, B. “Dimorphic effects of Notch signaling in bone homeostasis”. Nat. Med. 2008; 14(3): 299-305. PMCID: 2671578.
Engin, F., Lee, B. “Understanding of human birth defects through model organisms”. (Chapter 7), in Moody, S.A, ed. Principals of Developmental Genetics. Elsevier. 2007; 129-148.
Zhou, G., Zheng, Q., Engin, F., Munivez, E., Chen, Y., Sebald, E., Krakow, D., Lee, B. “Dominance of SOX9 function over RUNX2 during skeletogenesis”. Proc Natl Acad Sci. 2006; 103(50): 19004-9. PMCID: 1748167.